Output Displacement Error Evaluation of Multi-Degree-of-Freedom Mechanism Under Arbitrary Load Directions: Proposal of Evaluation Method and Stiffening of 3-Degree-of-Freedom Spatial Parallel Mechanism (Mechanical Dynamics, Measurement, Automatic Control)
January 2005
in “
日本機械学會論文集. C編
”
TLDR Minoxidil sulfate and pinacidil promote hair growth likely by increasing blood flow, not by activating K channels.
The study investigated the effects of minoxidil sulfate and pinacidil, known K channel openers, on hair follicle cells, specifically outer root sheath cells and dermal papilla cells. Using patch clamp techniques and 86Rb efflux studies, researchers found that these cells exhibited two types of Ca(2+)-activated K channels with specific conductances. However, neither minoxidil sulfate nor pinacidil activated these K channels or increased 86Rb efflux, suggesting that their hair growth-promoting effects might be due to mechanisms other than direct K channel activation, such as increased blood flow.
