research New-Onset Systemic Lupus Erythematosus During Pregnancy: A Challenge in Diagnosis
Diagnosing new systemic lupus during pregnancy is hard but important for the health of the mother and baby.
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research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management
The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.
research Neuroma of Radial Nerve After Surgical Correction of Secondary Lesion of Humeral Diaphyseal Fracture
Surgery to fix a broken upper arm bone can sometimes lead to nerve damage.
research Does Post-Void Residual Volume Predict Worsening Urological Symptoms in Patients with Multiple Sclerosis?
Post-void residual volume does not predict worsening urological symptoms in multiple sclerosis patients.
research Sub-Acute Cutaneous Lupus Erythematosus Following Nitrofurantoin: Causative or Coincidental?
Nitrofurantoin may cause sub-acute cutaneous lupus erythematosus.
research Generalized Hair-Follicle Hamartoma
The document described a unique syndrome of progressive baldness caused by a distinctive hamartoma of the hair follicle. The patient exhibited symptoms including myasthenia gravis, an enlarged sella turcica, an abnormal urinary amino acid pattern, and was suspected of having lupus erythematosus. Initially diagnosed as alopecia universalis, multiple skin biopsies later identified a basal cell hamartoma in each hair follicle. Histochemical and electron microscopic studies revealed the tumor's epithelial cell characteristics. The study highlighted the importance of skin biopsy in diagnosing alopecia of unknown origin and suggested that further research into abnormal ectodermal tissues could offer insights into hair keratin defects.
research New Therapeutic Approach to the Hirsute Patient
Spironolactone can reduce hair growth in women with hirsutism.
research C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
research Maximum Efficacy of Finasteride Is Obtained Within 6 Months and Maintained Over 6 Years
Finasteride works best in 6 months and lasts 6 years.
research Modeling of Chronic Radiation-Induced Cystitis in Mice
Researchers developed a mouse model that successfully mimics the bladder damage seen in humans after radiation therapy.
research Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study
Daughters of women with PCOS generally experience normal puberty but may have more body hair and different body fat distribution.
research Riboflavin-Responsive Glutaryl CoA Dehydrogenase Deficiency
Taking riboflavin and eating less lysine can help some people with a specific genetic disorder avoid brain damage.
research Feasibility of Repairing Full-Thickness Skin Defects by iPSC-Derived Epithelial Stem Cells Seeded on a Human Acellular Amniotic Membrane
iPSC-derived stem cells on a special membrane can help repair full-thickness skin defects.
research Therapeutic Effects of Stem Cells in Different Body Systems: A Comprehensive Review
Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.
research Cystitis Due to Cytoxan: Case Report
A woman developed severe bladder inflammation after cancer treatment with Cytoxan.
research Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria.
The study focused on a 27-year-old woman with hereditary coproporphyria, characterized by recurrent renal pain, dark urine, and hair loss, but no photosensitivity. Elevated urinary porphyrin metabolites and fecal studies confirmed the diagnosis, with decreased coproporphyrinogen oxidase activity at 35% of normal levels. Her mother and sisters were identified as heterozygous carriers of the condition, showing reduced enzyme activity up to 50%. A novel mutation was discovered in the coproporphyrinogen oxidase gene, involving a cytosine to thymine transversion at nucleotide position 854. Immunological studies indicated decreased enzyme protein concentrations in the patient and her family members.
research Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men
Topical spironolactone cream doesn't cause hormone-related side effects in the body.
research Platelet-Rich Plasma: A Promising Regenerative Therapy in Gynecological Disorders
Platelet-rich plasma shows promise for treating various female reproductive health issues but requires more research.
research The Clinical Applications of Five-Alpha Reductase Inhibitors
Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.
research Case Report: Heterozygous Mutation in HTRA1 Causing Typical Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
A heterozygous mutation in HTRA1 can cause severe CARASIL symptoms.
research Canine Alopecia X-Like Disorder
The dog likely has a condition similar to Canine alopecia X.
research Prevalence of Respiratory Disorders in Patients With Cleft Lip and Palate: Systematic Review
People with cleft lip and palate often have respiratory problems.
research Analysis of Benign Prostatic Obstruction Surgery: A Long-Term Evaluation in a Real-Life Context
Prostate surgery is often effective long-term, but some patients may need more treatment or another surgery, especially if they had prostatitis before.
research 5-Alpha Reductase Inhibitors: New Evidence on Benefits and Harms Beyond Benign Prostatic Hyperplasia
5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.
research Evaluation of Coronary Sinus Strain in Patients with Dipper and Non-Dipper Hypertension
People with non-dipper hypertension have higher aldosterone levels, more strain on their heart's venous system, and increased risk of endothelial dysfunction.
research Clinical Analysis of Systemic Lupus Erythematosus in the Elderly for 33 Cases
Elderly SLE patients show fewer typical symptoms and more hormonal side effects.
research 66-Year-Old Woman With Painless Vesicular Lesions
A woman was diagnosed with porphyria cutanea tarda and improved with phlebotomy and lifestyle changes.
research The Influence of Portocaval Shunting on Inner Ear Structures
PCS rats show significant inner ear damage and zinc deficiency, similar to liver cirrhosis patients.
research Every Transurethral Resection of the Prostate Is Not Just Benign Prostatic Hyperplasia
TURP specimens should be checked for various tumors, not just common prostate issues.
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.