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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Diagnosing and treating PCOS is complex due to differing criteria and requires a team approach.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

A woman's rare benign tumor that released both cortisol and testosterone was successfully removed, improving her health.

Non-surgical treatments like thread lifts, PRP therapy, HIFU, and radiofrequency effectively rejuvenate and tighten facial skin.

Eosinophilic cystitis is often misdiagnosed, but accurate diagnosis and treatment improve outcomes.

A woman's virilization symptoms were caused by her partner's use of testosterone cream, which resolved after they separated.

GnRH analogue can help diagnose ovarian causes of high testosterone in postmenopausal women when scans don't show the cause.

Ovarian vein sampling helped diagnose rare ovarian tumors causing high testosterone, and surgery to remove the tumors lowered the testosterone levels.

A 75-year-old man lost weight, hair, and nails due to severe stomach and intestine inflammation.

A baby girl had two brain-related growths removed and is developing normally.

Using LC-MS/MS for hormone measurement can prevent false high testosterone results and avoid unnecessary tests.

A woman's Cushing's syndrome caused by adrenal cancer improved after surgery.

A woman had a rare liver tumor causing male-like physical changes, highlighting the need for thorough checks when such symptoms appear.

Recurrent vaginal bleeding in young girls without puberty signs may require a genital exam to find hidden causes.

Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.

A rare ovarian tumor caused high testosterone in a postmenopausal woman, resolved by surgery.

Bilateral salpingo-oophorectomy resolved hyperandrogenism in a postmenopausal woman with rare ovarian tumors.

A woman's ovarian fibroma caused high testosterone levels, which normalized after surgery.

High-resolution MRI can distinguish between tertiary androgenetic alopecia and severe alopecia areata by measuring scalp and tissue thickness and hair follicle depth.

CT scans can find serious prostate cancer even when PSA levels are low.

A woman with a rare ovarian tumor and hyperparathyroidism improved after surgery, highlighting the need for reporting unusual cases to understand and manage rare diseases.

Removing one ovary helped treat a woman's severe PCOS symptoms when medicine didn't work.

A rare ovarian tumor that produced testosterone caused a blood clot in the lungs and increased red blood cells in a woman.

A woman's severe insulin resistance improved with treatment, but she still had high testosterone levels due to ovarian issues.

A gluten-free diet fixed a man's severe stomach pain and bowel issue related to celiac disease, but not much his hair loss.

Surgical robots have improved but still can't perform tasks or make decisions on their own.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.