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    Glossary Tyrosine Kinase Inhibitors

    block enzymes that regulate cell growth and division

    Tyrosine Kinase Inhibitors (TKIs) are a class of medications that block the action of enzymes called tyrosine kinases, which are involved in the signaling pathways that regulate cell division and survival. By inhibiting these enzymes, TKIs can help to slow down or stop the growth of cancer cells, making them a valuable treatment option for certain types of cancer.

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    Research 30 of 1000+

    1. Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects Current drug metabolism · 2009 · 508 citations
    2. Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia Dermatology · 2015 · 32 citations
    3. Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia Journal of the American Academy of Dermatology · 2013 · 25 citations
    4. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    5. Tyrosine kinase Inhibitors in Dermatology: A Systemic Review Journal of dermatology and dermatitis · 2021 · 1 citations
    6. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    7. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    8. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    9. Effets secondaires cutanéo-muqueux des nouvelles molécules anticancéreuses: Inhibiteurs de l'EGF-R, inhibiteurs de tyrosine kinase et stabilisateurs du fuseau mitotique 2011
    10. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    11. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    12. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    13. Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea Frontiers in Endocrinology · 2019 · 39 citations
    14. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    15. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    16. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    17. Comparison of pemetrexed and docetaxel as salvage chemotherapy for the treatment for nonsmall-cell lung cancer after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors Journal of international medical research · 2014 · 12 citations
    18. Cerebral Ischemia Related to Isotretinoin; Venlafaxine-Induced Alopecia; Cognitive Dysfunction with Tolterodine; Retinal Artery Occlusion after Injection of Long-Acting Risperidone; Olanzapine-Induced Chylomicronemia Presenting as Pancreatitis; Metabolic Effects of the Atypical Antipsychotics – an Editorial; Another Drug-Induced Pancreatitis – This One Caused by a Tyrosine Kinase Inhibitor; Suicide Attempts Related to Antidepressant Medications Hospital pharmacy · 2007
    19. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    20. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    21. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    22. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    23. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    24. Unraveling Ritlecitinib: an in-depth analysis of JAK3 inhibitor for the treatment of alopecia areata Expert Opinion on Drug Metabolism & Toxicology · 2024 · 2 citations
    25. Erlotinib-induced trichomegaly of eyelashes in lung cancer treatment: Epidermal growth factor receptor inhibitor side effect Dermatology Online Journal · 2025
    26. JAK INHIBITORS IN THE PATHOGENESIS OF ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    27. JAK INHIBITORS IN THE PATHOGENESIS OF ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    28. Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs Journal of pharmacy & pharmacognosy research · 2024
    29. Efficacy and Tolerability of Brevilin-A, a Natural JAK Inhibitor, in Pediatric Alopecia Areata: A Case Series Clinical Cosmetic and Investigational Dermatology · 2024
    30. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021