Severe Scarring Alopecia Associated with Combinational Use of Ficlatuzumab and Gefitinib: A Clinical and Immunohistochemistry Study

    December 2012 in “ Journal of dermatological science ”
    Yang Hsin Shih, Chia‐Yu Chu
    TLDR Combining ficlatuzumab and gefitinib can cause severe scarring hair loss.
    The study investigated the effects of combining ficlatuzumab, an anti-hepatocyte growth factor monoclonal antibody, with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in treating non-small cell lung cancer (NSCLC) among Asian patients. The combination aimed to address resistance to EGFR TKIs, which is common after prolonged treatment. However, the study found that this combination was associated with severe scarring alopecia, a significant adverse effect. The findings highlighted the need for careful consideration of side effects when developing combinational cancer therapies.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 402 results

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community 3 Doctors 3 Diagnoses: Please help.

      in Treatment  4 upvotes 9 months ago
      A user experiencing hair loss received three different diagnoses: androgenic alopecia, traction alopecia, and scarring alopecia, and tried treatments like minoxidil and finasteride without success. They are considering dutasteride but were advised to seek anti-inflammatory medication instead.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 8 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community TE turned into Scarring hairloss

      in Update  12 upvotes 8 months ago
      The user experienced hair loss due to a crash diet and later developed scarring hair loss. They are now on finasteride, oral minoxidil, LDN, Zyrtec, and Oztela to reduce scalp inflammation and promote hair regrowth.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

    Related Research

    1 / 1 results