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Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.

Serenoa repens and N-acetyl glucosamine/milk proteins complex may help with hair growth and prevent hair loss.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Finasteride harms Daphnia magna's reproduction, growth, and metabolism.

Using a laser helmet with Minoxidil works better for male hair loss than Minoxidil alone, with no extra side effects.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Testosterone undecanoate safely and effectively increased penis size in male children with 5-alpha-reductase deficiency.

Finasteride and dutasteride may help prevent hair loss but could cause side effects like sexual dysfunction and psychological issues.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Chinese medicine may help treat hair loss by affecting genes and enzyme activity.

New compounds may soon be tested to treat excessive hair growth in women.

Finasteride helps treat hair loss by blocking enzyme activity.

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.