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This study found that among patients with inflammatory bowel disease, those with the NUDT15 mutation had a reduced tolerance for thiopurine dosage over the long term and were more likely to require hospitalization and surgery compared to those without the mutation.

This study found that PRMT5 inhibitors showed potent anti-tumor activity in models of adenoid cystic carcinoma and that combining these inhibitors with lenvatinib may have additional growth-inhibitory effects.

Teledermatology reduces unnecessary in-person visits and improves care.

This study demonstrates that Krt15 marks long-lived, multipotent, and injury-resistant crypt cells in the small intestine, which may serve as the cell of origin in intestinal cancer.

In this study, researchers found that the NUDT15 R139C gene variant is a significant genetic risk factor for azathioprine-induced severe myelotoxicity in Japanese patients with dermatological conditions, suggesting that screening for this variant may help prevent adverse reactions in East-Asian populations.

This study reports that sacituzumab govitecan achieved a 33.3% overall response rate in patients with metastatic triple-negative breast cancer who had prior treatments, with a median response duration of 7.7 months.

In this study, researchers found that the gene LRRC15 was overexpressed in dermal papilla cells from balding areas compared to non-balding areas in patients with androgenetic alopecia.

This study found that CK15 is an unreliable marker for assessing bulge zone integrity in cicatricial alopecia follicles due to its altered expression in diseased conditions.

In this study, ALRV5XR significantly increased hair regrowth in women with androgenetic alopecia or telogen effluvium, with no adverse events reported.

This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.

This study found that using an LED array with an 863 nm wavelength delayed tumor development and reduced systemic inflammatory cytokines in DMBA/TPA-induced mouse skin tumors, suggesting potential but limited benefits of light therapy.

This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.

This study evaluated the real-world safety of Tepotinib for treating NSCLC with METex14 skipping mutations, confirming known adverse events and identifying new signals like deafness and taste disorder, especially highlighting early monitoring.

This study suggests that low-dose IL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.

This article discusses the impact of PROTACs technology in transforming drug discovery with its novel degradation mechanism, but it reports no new experimental findings.

This study found that WNT10A is significantly upregulated in human esophageal squamous cell carcinoma and is associated with enhanced tumor cell migration, invasion, and poor survival.

This review examines the role of IL-15 in alopecia areata treatment but reports no clinical results, as there are currently insufficient studies to determine its therapeutic potential.

In this study, both physician and patient reports revealed that more severe alopecia areata was associated with higher emotional symptoms and greater activity limitations among patients.

This study found an increased risk of asthma and allergic rhinitis in individuals with hidradenitis suppurativa.

This study suggests that keratin 15 and Id3 proteins play distinct roles in epithelial and dermal cell activities during the regeneration stages of rat vibrissae hair follicles.

This pilot study suggests that topical melatonin may protect hair follicle stem cells from paclitaxel-induced damage, potentially preventing chemotherapy-induced alopecia and enhancing the effects of scalp cooling caps.

This study found that the overexpression of the lncRNA HOTTIP in glioma cells increased resistance to the chemotherapy drug temozolomide, suggesting a key role for miR-10b and EMT processes in this resistance.

In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.

This article discusses the mechanisms behind chemotherapy-induced alopecia and the potential for permanent hair loss due to irreversible damage to hair follicle stem cells, but it reports no new clinical findings.

This study suggests that Elf5 plays a crucial role in regulating stem cell processes involved in skin and hair follicle development and regeneration, impacting cell proliferation and differentiation.

This phase I study reported that ETC-159, targeting Wnt signalling, showed tolerable safety profiles at doses that inhibit its pathway, though bone turnover markers increased, warranting early and regular monitoring. No tumor responses were observed, but two patients achieved stable disease for several cycles.

This study concluded that topical betamethasone valerate lotion is more effective than 15% lactic acid solution for managing multiple patchy alopecia areata over a 12-week period in a sample of 50 patients.

This article is an abstract header with author credentials and reports no study findings.