Influence of NUDT15 Genotyping on Dose Intensity of Thiopurine Administration and Long-Term Clinical Outcomes
August 2023
in “
Research Square (Research Square)
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Studysummary This study found that among patients with inflammatory bowel disease, those with the NUDT15 mutation had a reduced tolerance for thiopurine dosage over the long term and were more likely to require hospitalization and surgery compared to those without the mutation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study evaluated the long-term effects of NUDT15 genotyping on thiopurine dosage and clinical outcomes in patients with ulcerative colitis (130 cases) and Crohn’s disease (55 cases) over a median period of 7.8 years. Patients with NUDT15 mutations (n = 48) required lower daily thiopurine dosages and had shorter times to dose reduction and discontinuation compared to the wild-type group (n = 137). The mutation group also had a higher tendency for hospitalizations and significantly more surgeries. In ulcerative colitis, discontinuation of thiopurines was linked to increased hospitalization and surgery risks. In Crohn's disease, NUDT15 SNPs were directly associated with higher hospitalization and surgery rates. The findings highlight the importance of personalized thiopurine dosing to improve long-term outcomes in these patients.
