November 2022 in “Journal of Investigative Dermatology” This study found a minimal overall contribution of rare coding variants to male-pattern hair loss but identified significant associations with rare variants in 125 genes, including novel candidate genes.
April 2025 in “Journal of Bioscience and Bioengineering” Centrifugal forces can help prepare hair follicle germs for hair regeneration.
9 citations
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January 2019 in “Skin appendage disorders” This study found that among patients with seborrheic dermatitis, the "dandelion" vascular conglomerate observed through trichoscopy was correlated with Malassezia scalp colonization.
14 citations
,
May 1979 in “International Journal of Dermatology” In this study, trichostasis spinulosa was observed in 51 patients with lesions on the nose, where some follicles contained up to 86 hairs each, possibly influenced by endocrine factors and actinic rays.
87 citations
,
August 1974 in “Journal of Investigative Dermatology” 26 citations
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December 1979 in “Journal of Cutaneous Pathology” This study found that trichostasis spinulosa was present in some seborrheic keratoses, indicating they may partly originate from hair follicle cells.
2 citations
,
January 2016 in “Skin pharmacology and physiology” This study found that seed oil of Caragana korshinskii demonstrated high antifungal efficacy against Trichophyton mentagrophytes in an in vivo guinea pig model of dermatophytosis.
September 2001 in “Swiss Medical Forum ‒ Schweizerisches Medizin-Forum” 8 citations
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January 2014 in “Indian Dermatology Online Journal” This article presents a case of trichostasis spinulosa, a common but often unrecognized disorder, diagnosed through dermoscopic examination of black macules revealing bundled vellus hairs, with the patient declining treatment.
In this study, a gel formulation with Fenugreek seed extract demonstrated beneficial effects in reducing hair splitting among patients compared to placebo.
In this animal study, treatment with Trachyspermum copticum seed extract significantly altered IL-1 and KGF/FGF-7 gene expression, improving dermatitis and hair growth in mice compared to controls and corticosteroids.
2 citations
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June 2001 in “Medical Electron Microscopy” This study observed that the keratinization pattern of trichilemmal cysts in two Japanese women may originate from the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.
12 citations
,
March 1981 in “International Journal of Dermatology” This case study reports that selenium shampoo, bacterial infection with trichomycosis axillaris, and possibly strongyloides larvae may have contributed to acquired hair shaft abnormalities resembling trichorrhexis nodosa in two patients.
11 citations
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November 1996 in “Pediatric dermatology” This paper reviews trichostasis spinulosa and presents a case in a 13-year-old girl, providing no new clinical research results.
December 2022 in “Research journal of topical and cosmetic sciences” This study evaluated a herbal anti-dandruff hair wash powder, TRICHONEMTM, composed of eighteen herbal ingredients, reporting effective in vitro anti-dandruff activity and high user satisfaction in a 4-week pilot trial involving 50 women, without causing irritation.
44 citations
,
August 2008 in “Archives of Dermatology” This abstract provides no results; it is a website notification about cookies and general access to JAMA content.
May 2020 in “JOJ Dermatology & Cosmetics” This report describes a rare case of Trichostasis Spinulosa on the heel, an uncommon location for this type of lesion.
4 citations
,
January 2024 in “Scientific Reports” Pumpkin seeds may help expel parasites, but findings are retracted.
5 citations
,
January 2013 in “Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery” This study found that a polyherbal formulation of Trigonella foenum-graecum and Butea monosperma significantly promoted hair growth and reduced DHT levels in a chemotherapy-induced alopecia model.
9 citations
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January 2012 in “International journal of trichology” This case report suggests that Trichostasis spinulosa should be considered in diagnosing treatment-resistant open comedone-like lesions and that skin surface biopsy might be an effective diagnostic method.
January 2026 in “Surgical & Cosmetic Dermatology” 3 citations
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September 1973 in “Archives of dermatology” This study reports that daily topical application of a 0.05% tretinoin solution can eliminate the hair plugs and symptoms associated with trichostasis spinulosa.
13 citations
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January 2018 in “Skin Appendage Disorders” This study found that dermoscopy improves clinical diagnosis accuracy for trichostasis spinulosa and proposes a new dermoscopic classification with implications for treatment outcomes.
December 2025 in “International Journal of Ayurvedic Medicine” This review reports that Fenugreek seeds contain compounds like Galactomannan and Trigonelline, which show anti-diabetic and anti-hyperlipidemic effects, while Fenugreek leaves have high saponin content, contributing to their anti-microbial activities.
13 citations
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January 1985 in “International Journal of Dermatology” This study compared trichostasis spinulosa with keratosis pilaris and eruptive vellus hair cysts, finding differences in lesion distribution and microscopic appearance.
8 citations
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August 2018 in “Anais Brasileiros De Dermatologia” Researchers translated and validated the WAA-QoL questionnaire into Brazilian Portuguese, finding it to be a reliable tool for assessing quality of life in women with female pattern hair loss.
4 citations
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November 2015 in “Research Journal of Medicinal Plant” This study found that ethanolic, aqueous, and hydroethanolic extracts of Tridax procumbens inhibited mitosis and caused mutagenic effects on cell division in Allium cepa root meristematic cells.
27 citations
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October 2002 in “International Journal of Dermatology” This study presents a microscopic analysis of the pruritic variant of trichostasis spinulosa in two patients and reviews existing literature, reporting no new clinical results.
October 2015 in “CRC Press eBooks” This article reviews the use of trichoscopy for diagnosing and monitoring various scalp conditions, but it presents no new experimental findings; the authors emphasize its precision in noninvasive evaluation.
August 2026 in “Genetics and Molecular Research” This study found that hydroalcoholic extracts of Trigonella foenum-graecum L. seeds were rich in bioactive phytochemicals and demonstrated potential therapeutic properties against dandruff, alopecia, and oxidative stress through molecular docking analysis of key constituents such as diosgenin, kaempferol, and quercetin.