Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

In the 2018 study, researchers found that an aqueous extract of Trachyspermum copticum (L.) Link seeds significantly affected gene expression levels of IL-1 and KGF/FGF-7 in a mouse model of irritant contact dermatitis. The extract led to a 2 to 3-fold increase in IL-1 gene expression and significant changes in KGF/FGF-7 gene expression compared to untreated mice. These changes were associated with improved skin healing and increased hair growth at the site of dermatitis. The extract was more effective than corticosteroid treatment, which resulted in thin skin and fragile hair. The study suggests the extract's potential as a treatment for cutaneous inflammation and hair growth promotion, recommending further research to understand its mechanisms and clinical trials for human application.