June 2024 in “Annals of Medicine and Surgery” This case report highlights the rare co-occurrence of Pili Annulati and Trichorrhexis Nodosa in a Syrian woman, underlining the need for further research into their relationship and treatment.
This study suggests that topically applied thyroid hormones T3 and T4 promote hair growth on human scalp tissues ex vivo, highlighting potential therapeutic use for hair loss conditions like androgenetic alopecia.
January 2024 in “Diagnostic cytopathology” In this case report, the authors observed that understanding the cytological features of trichilemmal carcinoma is crucial for accurate FNAC diagnosis of its metastases in head and neck regions.
2 citations
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August 2007 in “Zoonoses and Public Health” This study documented clinical cases of dermatophytosis in two free-ranging southern chamois in the Eastern Pyrenees, with Trichophyton mentagrophytes identified in both animals.
7 citations
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May 2010 in “Journal of Cutaneous Pathology” This study identified a novel locus for hereditary hypotrichosis simplex on chromosome 13q12.12~12.3 in a four-generation Chinese family.
40 citations
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February 1946 in “Canadian Journal of Research/Canadian journal of research” This study observed that the hair loss in homozygous rhino mice is associated with widening of the hair canal due to hyperkeratosis, leading to insufficient support for hair anchoring.
March 2022 in “Ophthalmology Journal” This case report describes a 45-year-old woman with a trichoadenoma of the eyelid, emphasizing the importance of histopathological examination for accurately diagnosing excised eyelid lesions.
2 citations
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January 2020 in “BioMed Research International” This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.
January 2006 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review discusses the characteristics and diagnosis of loose anagen hair syndrome in children and reports no new clinical results.
April 2026 in “Cosmetics” In this randomized, double-blind, placebo-controlled trial, researchers found that a multi-targeted cosmetic formulation containing TrinogeniX™ significantly increased hair density and thickness in individuals with androgenetic alopecia without adverse effects, suggesting it as a potential safe and effective treatment option.
36 citations
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March 2011 in “Nature Communications” This study found that TSC2-null fibroblast cells from TSC skin hamartomas can induce hair follicle formation and hamartomatous changes in keratinocytes, with active mTOR signaling observable in a mouse xenograft model.
July 2002 in “Science s STKE” In this study, the researchers reported that altering β-catenin signaling in a transgenic mouse model led to changes in skin cell fate, notably converting hair follicle cells into epidermal cells and forming cysts instead of follicles.
1 citations
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December 1997 in “Archives of dermatology” This report describes a case of trichostasis spinulosa, a condition with pruritic, black papules on the face caused by keratotic plugs with embedded vellus hairs.
2 citations
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July 2019 in “Indian dermatology online journal” This report documents a rare case of familial eyelash trichomegaly and synophrys in three siblings, with one sister also having loose anagen hair syndrome, an unreported association.
20 citations
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August 2007 in “Molecular therapy” This study found that inducing hair follicles into the anagen-onset stage in mice enhances the immune response to a topically applied DNA vaccine against anthrax.
July 2025 in “International Journal of Trichology” This study reported six pediatric cases of temporal triangular alopecia and highlighted the use of trichoscopy to distinguish it by detecting a distinctive carpet of vellus hair, helping to differentiate TTA from other hair loss conditions.
1 citations
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May 2003 in “Archives of Pathology & Laboratory Medicine” This report discusses a case of pediatric trichotillomania, detailing its clinical presentation and distinguishing histopathological characteristics, ultimately diagnosing the condition in a 7-year-old boy with nonscarring alopecia.
October 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study demonstrates that using a K15 promoter-driven GFP labeling technique allows for the identification and characterization of epithelial stem cells in adult human hair follicles.
March 2004 in “Journal of the American Academy of Dermatology” A rare fungal infection caused hair loss in a North American infant.
119 citations
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November 2016 in “American journal of human genetics” This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.
January 2006 in “Chieh P'ou Hsueh Pao” In this study, the researchers observed that transfecting hair follicle cells with an amino-terminal truncated beta-catenin gene significantly increased cell proliferation, potentially by enhancing c-myc gene expression.
April 2025 in “Asian Journal of Case Reports in Surgery” This case report of a 60-year-old male patient diagnosed with trichilemmal carcinoma, initially mistaken for a sebaceous cyst, highlights the importance of careful evaluation of atypical swellings for correct diagnosis and treatment.
April 2014 in “Jurnal Biomedik : JBM” This case report diagnosed an 8-year-old girl with trachyonychia and secondary onychomycosis, finding that spontaneous improvement is common, making specific therapy often unnecessary despite treatment challenges with associated fungal infections.
1 citations
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December 2017 in “Acta biomedica scientifica” This study observed that 30% of women with polycystic ovary syndrome had androgenic alopecia, suggesting it is a prevalent but unreliable marker of hyperandrogenism.
June 2026 in “Indian Journal of Dermatology Venereology and Leprology” In this study, researchers found significant associations between trichoscopic features and the severity of androgenetic alopecia in Korean participants, suggesting trichoscopy as a useful tool for early detection and monitoring by identifying indicators like vellus hairs and follicular unit changes.
April 2026 in “Research Square” In this study, trichoscopic examination revealed that variations in hair diameter were more common in certain types of alopecia affecting the frontal scalp, suggesting the importance of evaluating the entire scalp for accurate diagnoses, although limitations include a single center design and small sample size.
23 citations
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July 2003 in “Journal of Investigative Dermatology” Genetic testing for hairless gene mutations is crucial to correctly diagnose and treat atrichia with papular lesions.
7 citations
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May 2013 in “PubMed” In this randomized, placebo-controlled study, the tested cosmetic ingredient containing Trifolium pratense flower extract and a biomimetic peptide increased anagen hair and improved the anagen/telogen ratio over four months in individuals with recessing hair.
January 1996 in “Studia iuridica” This study identified two novel point mutations in the hHb6 gene associated with monilethrix, suggesting these mutations could serve as diagnostic markers for this genetic hair disorder.
21 citations
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September 1997 in “British Journal of Dermatology” This study found that monilethrix in three unrelated European families is linked to the type II keratin gene cluster on chromosome 12q13, with no evidence of defects in type I keratins.