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Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

Recombinant keratin K31 makes damaged hair thicker, stronger, and straighter.

Keratinized wool cells still have some organelles like lysosomes and mitochondria.

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

Some hair protein genes evolved early and were adapted for use in hair follicles.

Notch-related genes play a key role in the development and cycling of hair follicles.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Two patients with the same genetic mutation had both blistering skin and easily pulled out hair.

HOXC13 is essential for hair and nail development by regulating Foxn1.

Estrogen therapy helped regrow hair in a bald man.

Cats with abnormal hair had DSG4 gene changes causing hair problems.

Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Rac1 is essential for proper hair structure and color.

Some hair loss disorders are caused by genetic mutations affecting hair growth.

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

ILK is essential for skin development, pigmentation, and healing.

Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.

Desmoglein 4 is controlled by specific proteins that affect hair growth.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

Scalp involvement is common in pemphigus and can lead to hair loss, with the severity of scalp lesions linked to overall disease severity.

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

Hair keratin-associated proteins are essential for strong hair, with over 80 genes showing specific patterns and variations among people.

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.

The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.