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    Did you mean Transgenic Mouse Model?
    Glossary Transgenic Mouse Model

    A transgenic mouse model is a genetically modified organism that has had a foreign gene inserted into its genome, allowing researchers to study the effects of specific genes on biological processes, including hair loss and hair biology. These models are particularly relevant in the field of hair research as they can mimic human hair loss conditions, such as androgenetic alopecia or alopecia areata, providing insights into the underlying mechanisms and potential therapeutic targets. Key distinguishing characteristics of transgenic mouse models include the ability to control gene expression and the capacity to observe phenotypic changes in hair growth and follicle development in a living organism.

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    1. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998 · 79 citations
    2. Transgenic mouse models support HCR as an effector gene in the PSORS1 locus 2004 · 37 citations
    3. Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors Gene Expression Patterns · 2017 · 14 citations
    4. A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development 2002
    5. TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia Cell Death and Disease · 2016 · 38 citations
    6. Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris Journal of Dermatological Science · 2011 · 17 citations
    7. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 13 citations
    8. High‐Sulfur Protein Gene Expression in a Transgenic Mouse Annals of the New York Academy of Sciences · 1991 · 10 citations
    9. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Current Biology · 2001 · 338 citations
    10. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 43 citations
    11. HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion Journal of Investigative Dermatology · 2017 · 25 citations
    12. Two novel CreER<sup>T2</sup> transgenic mouse lines to study melanocytic cells in vivo Pigment Cell & Melanoma Research · 2022 · 1 citations
    13. Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology Enlighten: Publications (The University of Glasgow) · 2005
    14. Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation Radiation Research · 2022 · 5 citations
    15. G4, is a new transgenic mouse model for the polycystic ovaries syndrome 2019
    16. Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells heiDOK (Heidelberg University) · 2012
    17. Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin Biochemistry and Cell Biology · 1995 · 25 citations
    18. 2063-LB: Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups during the First Hair Cycle Diabetes · 2024
    19. Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration Drug Delivery · 2010 · 7 citations
    20. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    21. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001 · 13 citations
    22. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010 · 42 citations
    23. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions Experimental dermatology · 2000 · 20 citations
    24. Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics Journal of Investigative Dermatology · 2014 · 16 citations
    25. Is the “Comb Over” Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia) Endocrinology · 2010 · 3 citations
    26. Transgenic HPV11-E2 protein modulates URR activity in vivo Transgenic Research · 2023 · 2 citations
    27. Constitutive activation of Stat3 in mouse epidermis is linked to hair deficiency and cytoskeletal network damage Experimental Dermatology · 2015 · 1 citations
    28. Cloning and Activity of Mouse Ultra-High Sulfur Keratin Gene Promoter Acta Laboratorium Animalis Scientia Sinica · 2010
    29. Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing PLOS ONE · 2012 · 23 citations
    30. Insertional mutation of the hairless locus on mouse Chromosome 14 Mammalian Genome · 1993 · 19 citations