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30 / 1000+ resultsresearch Management of Transgenderism
This review discusses the therapeutic options for transgender individuals, including hormonal and surgical treatments, and reports no new clinical results; the authors highlight the need for more research on long-term effects.
research Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle
This study found that expression of certain mutant keratin genes in mice led to severe alopecia, suggesting a similar mechanism could cause hair loss in humans.
research Alopecia em transgêneros: uma discussão invisibilizada no universo científico
In this narrative review, the authors discuss the potential impact of hormone therapy on androgenetic alopecia among transgender individuals, especially transgender men using testosterone, and its adverse effects on emotional well-being and body image within a socially stigmatized population.
research Transplante capilar em transgêneros femininos: estudo de casos
This source describes two cases of hair transplantation in transgender patients with Androgenetic Alopecia, showing good results using Follicular Unit Extraction and Follicular Unit Transplantation techniques, highlighting the need for more research specific to this population.
research Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration
This study found that retinoic acid pre-treatment enhanced the efficiency of gene transfer into mouse skin for potential therapeutic applications.
research Animal models and culture methods in the study of hair growth
This study found that using a novel dissolving microneedle with valproic acid effectively enhances hair follicle regrowth through improved delivery and activation of the Wnt/β-catenin pathway compared to topical application.
research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
This review explores the advantages and limitations of using zebrafish models to study various skin diseases, but reports no new experimental results.
research Induced pluripotent stem cell line MUSIi006-A derived from hair follicle keratinocytes as a non-invasive somatic cell source
This study reported that reprogramming keratinocytes from plucked hair provides an easy, non-invasive, and efficient method for generating pluripotent iPSCs without the need for medical professionals or operating rooms.
research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis
This study found that the effects of the vitamin D receptor on hair follicle cycling in mice are independent of its ability to bind a hormone, with specific domain mutations influencing hair regrowth outcomes.
research Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.
Mice with extra sheep genes had hair that fell out and regrew in cycles.
research Restoration of Spermatogenesis and Male Fertility Using an Androgen Receptor Transgene
This study demonstrated that an AR-EGFP transgene can restore AR function and fertility in Sertoli cell-specific AR knockout mice, highlighting its potential use in understanding androgen receptor functions.
research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
This study found that overexpression of ornithine decarboxylase and activated Ha-ras together led to a high rate of tumor development in a mouse model without additional carcinogens.
research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN
This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.
research Hair Follicle Keratins
This review summarizes the proteins found in various hair follicle cells and discusses their roles in keratinocyte differentiation pathways, with no new experimental results reported.
research Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7
This publication reviews the World Professional Association for Transgender Health's Standards of Care for supporting transgender and gender nonconforming people, with adjustments needed for diverse global contexts and no new clinical results.
research A new tool for conditional gene manipulation in a subset of keratin‐expressing epithelia
This study reported that a Megsin-Cre transgene enables genetic manipulation primarily in skin, forestomach, and esophagus tissues, offering a new tool for studying development and diseases in these areas.
research Development of Heritable Melanoma in Transgenic Mice
This study reports that transgenic mice carrying Clone B DNA developed spontaneous melanomas likely due to an interruption in genes regulating cell growth in melanin-producing cells, offering a model for melanoma research.
research Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
research The Browning of White Adipose Tissue: Some Burning Issues
This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.
research Transgender adolescents and acne: A cases series
This article addresses the complexity of treating acne in female-to-male transgender adolescents undergoing testosterone therapy, highlighting concerns about co-administered treatments and their potential risks.
research One Transgene: Two Outcomes
In this study, the researchers reported that altering β-catenin signaling in a transgenic mouse model led to changes in skin cell fate, notably converting hair follicle cells into epidermal cells and forming cysts instead of follicles.
research The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome
This review discusses environmental epigenomics and its potential impact on gene regulation and phenotypic outcomes, using the Avy mouse model to illustrate nutritional and environmental effects on the fetal epigenome without presenting new findings.
research Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re‐discovered
This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.
research Organization and Expression of Hair Follicle Genes.
This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.
research Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene
This study found that in transgenic mice overexpressing a mutant hairless gene, changes in its expression affected hair loss and regrowth, implicating the gene's role in hair follicle biology.
research Commentary
Hair disease research is a growing and evolving field in dermatology, with recent significant advances.
research Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter
Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.
research Production of artificial synthetic spidroin gene 4S-transgenic cloned sheep embryos using somatic cell nuclear transfer
This research explored methods to obtain transgenic sheep embryos expressing synthetic spider silk genes in hair follicles using somatic cell nuclear transfer, with successful in-vitro development observed.
research Construction of Cashmere Goat Embryos Carrying K2.9 Gene by Transgenic Somatic Cell Nuclear Transfer Technology
This study concluded that transgenic somatic cell nuclear transfer technology can produce cashmere goat blastocysts carrying the K2.9 gene using specific fibroblast cells and activation methods.