Retinoic Acid And Dimethyl Sulfoxide Promote Efficient Delivery Of Transgenes To Mouse Skin By Topically Transdermal Penetration

    May 2010 in “ Drug Delivery ”
    Xiangjun Chen, Yinbing Zhang, Changyong Liu, Yan Zhang, Xikun Zhou, Taoyou Zhou, Yong-Qiu Mao, Bing Kan, Yuquan Wei, Jiong Li
    TLDR Retinoic acid and DMSO improve gene delivery to mouse skin for potential hair and skin disease treatment.
    The study explored a novel method for gene transfer to mouse skin, focusing on enhancing the expression of plasmid DNA in epidermis and hair follicle cells. By using dimethyl sulfoxide (DMSO) following pre-treatment with depilation and retinoic acid (RA), researchers found that RA pre-treatment significantly increased the efficiency of transfection. This approach suggested a more effective and cost-efficient strategy for employing gene therapy to treat hair and skin diseases.
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