January 2022 in “Bio web of conferences/BIO web of conferences” This study concluded that the elemental composition of tail brush hair in newborn calves can indicate trace element supply to the fetus during the last months of pregnancy.
July 2018 in “International journal of clinical & experimental dermatology” This narrative review describes the components of human hair and their nutritional importance but reports no clinical results; the authors suggest dietary sulfur amino acids are essential for hair health.
7 citations
,
January 2016 in “Hair therapy & transplantation” This study reported significantly lower levels of serum iron, ferritin, and calcium in young patients with premature gray hair compared to controls, implying that supplementation might prevent further graying.
581 citations
,
February 1998 in “The American Journal of Medicine” This review discusses the potential adverse effects of herbal remedies, such as allergic reactions and drug interactions, and reports no new clinical findings; the authors suggest the risks might be underestimated.
94 citations
,
September 2014 in “Therapeutic Delivery” This review describes recent advances in using nanoparticles for drug delivery to hair follicles, with potential applications in treating skin diseases such as alopecia and acne, but reports no new findings.
68 citations
,
May 2013 in “The American journal of medicine” This report documents two cases of severe systemic poisoning from heavy metals after short-term use of traditional Chinese medicines for treating damaged or infected tissue.
67 citations
,
January 2007 in “Environmental health perspectives” This case report highlights that a woman experienced arsenic toxicosis from kelp supplements, manifesting as alopecia and memory loss, which resolved after stopping the supplements.
13 citations
,
February 1995 in “Archives of Dermatological Research” In this study, gamma/delta T cells were observed in skin after allergic or irritant reactions to heavy metal salts, suggesting a role in skin defense against these metals.
8 citations
,
November 2023 in “Frontiers in Bioengineering and Biotechnology” This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.
5 citations
,
December 2014 in “Polish Journal of Public Health” This review discusses the mechanisms of zinc transport, its role in human health, and the effects of zinc imbalance, without reporting new results.
3 citations
,
May 2014 in “InTech eBooks” This review discusses the genetic and androgen-related factors in androgenetic alopecia, highlighting a specific polymorphism in the AR protein associated with male pattern hair loss, and reports no new clinical results.
15 citations
,
December 2014 in “PLoS ONE” This study identifies iRhom2 as a crucial regulator of hair follicle differentiation, showing that the iRhom2Uncv mutation leads to dysplasia and reduced TACE maturation, resulting in a hairless phenotype in mice.
2 citations
,
February 2025 in “Journal of Nanobiotechnology” In this study, metal-organic frameworks modified with stearic acid were used to deliver cardamonin to hair follicles, significantly promoting hair growth and cell proliferation in testosterone-challenged mice, suggesting potential benefits for androgenic alopecia treatment.
4 citations
,
January 2020 in “Skin appendage disorders” This study highlighted that toxic metals, particularly thallium, arsenic, selenium, and mercury, are commonly associated with cases of alopecia areata.
1 citations
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February 2024 in “International Journal of Physics Research and Applications” In this study, powdered milk samples from Senegal showed varying levels of heavy metals, with some exceeding acceptable maximum levels for calcium, potassium, and phosphorus, indicating potential safety concerns.
August 2025 in “International Journal of Nanomedicine” This review discusses metal-organic frameworks for treating diabetic infected wounds and related applications, reporting no new clinical results but highlighting challenges like biosafety and production for future research.
June 2025 in “Journal of Cluster Science” This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.
10 citations
,
January 2025 in “Biomaterials Science” This study found that a multifunctional hydrogel dressing enriched with Cu-MOF and tannic acid significantly improved full-thickness wound healing in rats, reducing the wound area to only 1.6% and promoting re-epithelialization, neovascularization, and hair follicle formation.
10 citations
,
January 2016 in “Elsevier eBooks” This chapter reviews the role of nanoparticles in wound healing, exploring current therapies, developments, and future directions, but reports no new clinical results.
4 citations
,
October 2022 in “Cell Reports Physical Science” This study developed a novel mineralization strategy using metal-polyphenol coordination for dynamic control of nano-scale processes, enhancing hydrogels that support wound healing with antibacterial and angiogenesis-promoting properties.
February 2026 in “Advanced Healthcare Materials” This study proposes a metal-organic gel-encapsulated microneedle system with antibacterial, anti-inflammatory, and pro-angiogenic properties for treating infected wounds, demonstrating potential for precise and adaptive management by targeting various stages of wound healing.
December 2025 in “Ciencia Latina Revista Científica Multidisciplinar” In this systematic review, researchers found that nanotopical systems like nanoparticles and liposomes significantly improved hair density, thickness, and follicular regeneration markers in alopecia treatment, sometimes surpassing traditional therapies like topical minoxidil, though methodological limitations remain such as insufficient long-term clinical trials.
June 2021 in “International Journal of Research in Medical Sciences & Technology” This article reviews various causes and treatments for alopecia, including nutritional deficiencies, stress, and hormonal changes, and reports no new clinical results.
3 citations
,
November 2023 in “American Journal of Men s Health” This study found that lower urinary tract symptoms in older men with benign prostatic hyperplasia negatively impact sexual function and mental health, suggesting the importance of early intervention to improve quality of life.
5 citations
,
January 2007 in “Lincoln (University of Nebraska)” These investigations described in the study demonstrate how geochemical techniques can be applied to biological studies in Yellowstone, finding significant mercury accumulation in trout and grizzly bears which correlates with hydrothermal sources.
September 2024 in “American Journal of Modern Physics” This study used X-ray fluorescence to analyze elemental and heavy metal contents in Senegalese powdered milk, finding potential safety concerns with excessive calcium in certain samples and significantly high potassium levels in one, suggesting ongoing monitoring is crucial for consumer safety.
7 citations
,
January 2002 in “Biological Trace Element Research” This study found that children with pituitary dwarfism had higher zinc and copper hair concentrations and lower manganese concentrations compared to healthy children.
6 citations
,
February 1998 in “PubMed” This study found that patients with MPA had significantly lower zinc and manganese levels and higher copper levels in their hair compared to hair-healthy men.
79 citations
,
October 2003 in “PubMed” In this study, PKCepsilon transgenic mice showed increased TNFalpha shedding during skin tumor promotion, which may contribute to the development of metastatic squamous cell carcinoma.