research Novel Inhibitors of 5α-Reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
Search
for
Sort by
Research
30-60 / 1000+ results 
research Ketoconazole as an Adjunct to Finasteride in the Treatment of Androgenetic Alopecia in Men
Ketoconazole shampoo with finasteride improves hair density in men with hair loss.
research Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats
Dosing time affects finasteride's effectiveness and safety in rats.
research High Circulating Estrone and Low Testosterone Correlate with Adverse Clinical Outcomes in Men with Advanced Liver Disease
Men with advanced liver disease and high oestrone and low testosterone levels have worse health outcomes.
research Estimating the Contribution of the Prostate to Blood Dihydrotestosterone
The normal human prostate does not significantly affect blood DHT levels.
research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways
Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.
research COVID-19 and Androgenic Status: Do Testosterone or Dihydrotestosterone Have a Pivotal Role?
Higher dihydrotestosterone may be linked to more inflammation in COVID-19 patients with low testosterone.
research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility
PNU157706 reduced rat sperm movement and fertility without affecting offspring health.
research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2
Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.
research Controversies Regarding Transdermal Androgen Therapy in Postmenopausal Women
Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.
research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men
The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.
research The Association of Male Pattern Baldness and Risk of Cancer and High-Grade Disease Among Men Presenting for Prostate Biopsy
Men with more advanced male pattern baldness have a higher risk of prostate cancer and more severe disease.
research Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia
5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.
research Androgen Levels and Semen Parameters Among Former Users of Finasteride With Persistent Sexual Adverse Effects
research Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia
New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.
research Acne
Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.
research A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women
Topical finasteride reduces hair loss and promotes hair growth in men and women.
research Effect of Testosterone, Dihydrotestosterone, Estradiol, and Cortisol on the Quality of Fresh and Cryopreserved Stallion Sperm
Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.
research Diagnosis of an Indistinct Leydig Cell Tumor by Positron Emission Tomography-Computed Tomography
A PET-CT scan successfully located a hard-to-find Leydig cell tumor in a woman with hormonal symptoms.
research Relations Between Sex Hormone Levels and Characteristics of Hair and Skin in Healthy Young Men
Higher androgen levels do not cause baldness in men.
research Parietal and Occipital Hair Loss Patterns in Initial Stages of Androgenic Alopecia in Men
Early-stage male pattern baldness shows two types of hair loss: one on the top of the head linked to hormonal changes, and another at the back of the head. The top hair loss responds well to specific treatment, while the back hair loss does not.
research Diagnosis of Hyperandrogenism: Biochemical Criteria
The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.
research Changes of Metabolic Profile in Men Treated for Androgenetic Alopecia with 1 mg Finasteride
Taking 1mg of finasteride daily can mildly improve metabolic health and glucose regulation in men with male pattern baldness.
research Finasteride Versus Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism
Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.
research Acute, Diffuse, And Total Alopecia
Two lotions used day and night may be a good alternative to minoxidil for hair loss, with better cosmetic effects and tolerance.
research Characteristics of Hyperandrogenism in Men
Older men with high total testosterone might not show symptoms, while younger men with hyperandrogenism may experience hair loss or acne.
research Active Ingredients for Treating Androgenetic Alopecia Provided by Different Brands
The document concluded that home treatments are needed for hair loss control, but professionals should better understand how these treatments work.
research Combination of an Antiandrogen and a 5α-Reductase Inhibitor: A Further Step Towards Total Androgen Blockade?
Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.
research Finasteride Reduces Total Cholesterol in LDLR-Deficient Mice
High doses of finasteride lower cholesterol and body weight in certain mice.
research Paradigm Shift in the Concept of Hormonal Milieu of Prostate Cancer
Prostate cancer risk is not linked to blood testosterone levels.