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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Videodermoscopy improves diagnosis of hair and scalp disorders and may reduce scalp biopsies.

About 6.5% of young Caucasian women in Spain have polycystic ovary syndrome.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Spironolactone treatment increases the amount of testosterone available in the body.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Diet changes can protect against harmful environmental effects on fetal development.

Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.