research Essential Role of STAT3 Signaling in Hair Follicle Homeostasis
STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.
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research The Biology and Clinical Application of Systemic Glucocorticoids
Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.
research Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair
The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
research DNA Dioxygenases Tet1/2/3 Control Cell Differentiation in Hair Follicle Keratinocytes via Modulating BMP Signaling Pathway
Tet1/2/3 enzymes affect hair follicle cell development by influencing BMP signaling.
research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis
Storing hair follicles in a special buffer with certain inhibitors can increase hair growth and improve transplant results.
research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells
FP-1 is a key protein in rat hair growth, active only during the growth phase.
research Transcriptional Control of Epidermal Stem Cells
Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.
research Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes
Signals from skin cells controlled by Rac proteins help turn certain precursor cells into white fat cells.
research Reconsidering PCOS Etiology, Diagnosis, Clinical Subgroups, and Subgroup-Specific Treatments
Different types of PCOS need specific diagnosis methods and treatments.
research The Hedgehog-GLI1 Pathway Is Important for Fibroproliferative Properties in Keloids and as a Candidate Therapeutic Target
Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.
research Murine Sebaceous Gland Homeostasis Requires Intact Cutaneous Innervation in a Hair Cycle-Dependent Context
Mouse skin glands need healthy nerves to grow properly during hair growth phases.
research Sex Hormones Modulate Pathogenic Processes in Experimental Traumatic Brain Injury
Sex hormones affect brain injury differently in males and females.
research Development of a Predictive Model for Iron Levels in Bovine Muscle Tissue Using Hair as a Predictor
Hair can accurately predict iron levels in cattle muscle, helping diagnose mineral imbalances.
research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability
Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.
research Investigation of a Non-Invasive Method of Assessing the Equine Circadian Clock Using Hair Follicle Cells
RNA from horse hair follicles can track circadian rhythms non-invasively.
research Targeted Expression of SV40 T Antigen in the Hair Follicle of Transgenic Mice Produces an Aberrant Hair Phenotype
SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.
research Skin CD4+ Memory T Cells Exhibit Combined Cluster-Mediated Retention and Equilibration with the Circulation
Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.
research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration
S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
research Whole Body and Regional Hemodynamic Effects of Minoxidil in the Conscious Dog
Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.
research Endoplasmic Reticulum Stress at the Crossroads of Progeria and Atherosclerosis
A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.
research Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort
Fluconazole can cause hair loss, but the exact cause is unknown.
research Hormonal Regulation and Systemic Signals of Skin Aging
Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.
research Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells
Apoptosis is essential for human skin development and forming a functional epidermis.
research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome
Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
research A Matter of Life and Death: Self-Renewal in Stem Cells
Stem cell self-renewal is complex and needs more research for full understanding.
research Stem Cell Heterogeneity and Plasticity in Epithelia
Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
research Estrogen Functions in Skin and Skin Appendages
Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
research The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells
The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.
research Primary Cicatricial Alopecia: Recent Advances in Understanding and Management
New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.