research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
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540-570 / 1000+ results research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.
research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90
Fibroblast changes in systemic sclerosis may help understand disease severity and treatment.
research A Study of the Differentiation Products of the Hair Follicle Cells with the Electron Microscope
Hair follicle cells become four types: medulla, cortex, cuticle, and inner root sheath.
research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta
Targeting TGFβ can improve skin immunity in older people.
research Developing New Graft Holding Solutions: In Vitro Evaluation of Bioactive Molecules Identifies Vitamin B12 as Micrograft Stabilizing Substance
Vitamin B12 improves the health and growth of hair micrografts.
research Zoonotic Majocchi's Granuloma of the Vulva
A woman and her guinea pig were successfully treated for a fungal infection.
research Bioengineering the Hair Follicle
Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.
research Emerging 3D Bioprinting Applications in Plastic Surgery
3D bioprinting in plastic surgery could lead to personalized grafts and fewer complications.
research In Vitro Hair Follicle Growth Model for Drug Testing
Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
research Effect of VEGF and Minoxidil on the Production of Arachidonic Acid Metabolites by Cultured Hair Dermal Papilla Cells
research Reversible Activation of c-Myc in Skin
The study explored the effects of activating the protooncogene c-Myc in the skin of transgenic mice, revealing that c-Myc activation led to rapid proliferation and disrupted differentiation of keratinocytes, resulting in conditions resembling precancerous lesions such as hyperplastic actinic keratosis. These changes were accompanied by angiogenesis and were reversible upon deactivation of c-Myc. Despite the potential for c-Myc to induce apoptosis, survival signals in the skin suppressed this effect, allowing for the development of benign, hyperproliferative lesions without progressing to malignancy. The study highlighted the role of c-Myc in skin homeostasis and its implications in skin carcinogenesis, suggesting that additional mutations would be necessary for malignant transformation.
research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors
Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
research Autologous Cell Therapy for Facial Wrinkles: Comparison of Autologous Fibroblast Therapy with Dermal Fillers
Autologous cell therapy can reduce facial wrinkles effectively.
research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles
Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
research Cutaneous Gene Therapy
Cutaneous gene therapy research, conducted over more than 20 years, explored both direct and indirect gene transfer methods using viral and nonviral vectors to treat inherited skin diseases and potentially systemic disorders. Despite reaching clinical phases, challenges such as gene expression loss and immune reactions persisted. The study highlighted the potential of epidermal and hair follicle stem cells in skin regeneration and gene therapy, with telomerase influencing hair growth and cell proliferation. Clinical trials, such as those for junctional epidermolysis bullosa, showed potential for long-term expression and phenotypic correction. The research also explored hair follicle gene therapy, noting that adenoviral-mediated expression of Sonic hedgehog (Shh) could enhance hair growth, suggesting potential benefits for alopecia treatment. The document concluded that advancements in vector development and gene expression control could make cutaneous gene therapy a viable option for various diseases.
research Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead
FUE hair transplant is a promising method with benefits like less scarring, but requires a skilled surgeon and can damage hair follicles.
research Highlighting Nuances of Blue Light Phototherapy: Mechanisms and Safety Considerations
Blue light therapy is safe for skin and may protect against UV radiation.
research Mycobacterium Avium Subspecies Hominissuis Infection in a Dog from Germany with Multifocal Alopecia, Exfoliative Dermatitis, Hypercalcaemia, and Subsequent Sebaceous Atrophy
A dog in Germany was successfully treated for a rare bacterial infection without spreading it to humans.
research Hair Root Activation by Anagen Grow: A Herbal Hair Growth Serum
Anagen grow, a herbal hair serum, effectively promotes hair growth and could be an alternative to finasteride and beneficial for Minoxidil users.
research Expression of Plectin-1 and Trichohyalin in Human Tongue Cancer Cells
Tongue cancer cells show more plectin-1 than non-cancer cells, but both have similar levels of trichohyalin.
research Generation of iPS-Derived Model Cells for Analyses of Hair Shaft Differentiation
Researchers created a mouse cell line to study hair growth and test hair growth drugs.
research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease
Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.
research Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology
Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.
research Update on Platelet-Rich Plasma and Platelet-Rich Fibrin for Dermatologic Surgery: Addressing Knowns and Unknowns
PRP and PRF show promise for hair growth but need more research for consistent and safe use.
research Effectiveness of Minimally Invasive Injectable Modalities in the Management of Androgenetic Alopecia Among Adults—A Systematic Review
Injectable treatments can effectively and safely improve hair growth in adults with androgenetic alopecia.
research Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial
Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.
research Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia
Scientists created cell lines from balding patients and found that cells from the front of the scalp are more affected by hormones that cause hair loss than those from the back.
research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity
A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.
research Bioengineering of Hair Follicle-Like Structure for Validation of Hair Growth Promoting Compounds
The method can test hair growth products using a lab-made hair-like structure that responds to known treatments.