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Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Zinc deficiency in children can cause skin issues and can be serious if not diagnosed and treated properly.

Biotin treatment can significantly improve hair loss and motor functions in certain metabolic disorders.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Blocking IL-12/IL-23p40 helped reverse severe hair loss in patients.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Zinc supplements may be needed to treat hair loss in hypothyroidism.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.