5 citations
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August 1983 in “PubMed” This study found that isozyme profiles in polyoma virus-induced tumors were consistent and distinctive for each tumor type, except for salivary and mammary tumors which shared a profile.
1 citations
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April 1936 in “Journal of Experimental Biology” This study found that injecting thymus gland extracts into albino rats significantly accelerated growth and morphological differentiation across generations, including earlier sexual maturation and development of features like hair and teeth.
February 2016 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study reports a novel mutation in the TP63 gene associated with T and B cell lymphopenia in an EEC patient, suggesting that EEC diagnosis should include TREC assay and evaluation for immunodeficiency.
111 citations
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June 2002 in “The EMBO Journal” This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.
86 citations
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October 2005 in “Experimental Dermatology” This review explores the role of Foxn1 in mammalian skin biology, discussing its influence on hair follicle function and the potential for further research to enhance understanding of epithelial differentiation.
16 citations
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September 2006 in “The Journal of Immunology” This study identified that mouse MILL1 and MILL2 are glycoproteins distinct from human MICA/B, primarily due to their association with β2-microglobulin and TAP-independent surface expression.
11 citations
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October 2004 in “Journal of Experimental Biology” This review discusses the lasting impact of a 1951 J. Exp. Biol. paper on skin grafting methods and transplantation tolerance, which significantly influenced the field of transplantation biology.
2 citations
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November 1996 in “Transplantation” This study found that intrathymic injection of recipient-type splenocytes into donor rats, combined with antilymphocyte antiserum, effectively prevented graft-versus-host disease for up to 300 days.
1 citations
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March 2012 in “Revue neurologique” This study reports that both a 9-month-old with phenylketonuria on a phenylalanine-free diet and mice on a deficient diet exhibited severe health issues, highlighting the need for cautious dietary management.
1 citations
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April 2007 in “The FASEB Journal” In this study, D6D knockout mice showed severe deficiency in AA and DHA, leading to unexpected effects on skin health, fertility, and immune cell development.
May 2023 in “The Journal of Immunology” In this study of C3H/HeJ mice, researchers observed that alopecia areata is associated with the expansion of exhausted-memory CD8 T cells in multiple organs, with autoreactive activation not fully explained by known mechanisms, shedding light on the immunological dynamics underlying the condition.
January 2025 in “Annals of Thoracic and Cardiovascular Surgery” This case report describes a 55-year-old woman with alopecia areata whose condition improved rapidly and did not recur after the surgical resection of a thymoma, suggesting a potential immunological link between alopecia areata and thymoma that warrants further investigation.
103 citations
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January 2011 in “Blood” This study found that thymus transplantation in infants with FOXN1 deficiency led to T-cell reconstitution and functional immunity, resolving serious infections and cytopenias.
May 2023 in “Surgical Case Reports” This case report describes a rare instance of thymoma associated with alopecia areata in a 60-year-old woman who had no signs of myasthenia gravis, highlighting the need for thoracic surgeons to consider alopecia in such cases due to its impact on quality of life.
This article hypothesizes that thymoma with aplastic anemia may result from abnormal autoimmune CD8+ T lymphocytes produced by the thymoma, potentially leading to other cytotoxic T-cell-mediated autoimmune diseases.
31 citations
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June 2011 in “Journal of the neurological sciences” In this case report, a patient with thymoma was observed to have four co-occurring paraneoplastic autoimmune disorders that improved after thymectomy, suggesting a possible link between thymoma and these conditions.
25 citations
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April 2012 in “Veterinary and comparative oncology” This study found that rabbits with thymomas treated with radiation therapy had a median survival time of 313 days, increasing to 727 days excluding early deaths, with lower body weight linked to decreased survival.
7 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that thymus transplantation in athymic mice resulted in T-cell-driven hair follicle depigmentation and loss, without multiorgan autoimmune disease, highlighting mechanisms of tissue-specific tolerance.
January 2024 in “Case Reports in Endocrinology” In this case report, significant improvements in a 58-year-old male with severe refractory myasthenia gravis and concurrent alopecia areata were observed following a cortisone taper, suggesting a potential therapeutic role, especially after thymectomy.
2 citations
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March 2019 in “Veterinary dermatology” The authors concluded that thymoma-associated paraneoplastic syndrome in cats may manifest as noninflammatory alopecia instead of exfoliative dermatitis, and should be considered when diagnosing multifocal noninflammatory alopecia.
October 2016 in “Veterinary record case reports” This article describes a case of feline exfoliative dermatitis associated with a suspected thymoma, diagnosed using histopathology and imaging, and does not report new research findings beyond the case description.
2 citations
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April 2013 in “PubMed” This review discusses non-motor symptoms in autoimmune myasthenia gravis and associated thymomas, highlighting abnormal T-cell clones as a contributing factor, but reports no new clinical results.
49 citations
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November 2012 in “Journal of neurology, neurosurgery and psychiatry” This review discusses non-motor symptoms in patients with thymoma-associated myasthenia gravis, suggesting these symptoms, which can be treatable, often go overlooked despite affecting multiple organs.
7 citations
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October 2020 in “Wiener medizinische Wochenschrift” This paper presents a case study of a 21-year-old male with thyroid hemiagenesis, where the left thyroid lobe and isthmus are absent, and discusses the anomaly's potential clinical consequences based on existing literature.
21 citations
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December 1997 in “The Journal of Dermatology” In this case report, a 57-year-old Japanese woman with alopecia areata, associated with myasthenia gravis and thymoma, showed significant improvement after undergoing thymectomy and receiving high doses of glucocorticosteroids.
29 citations
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July 2008 in “British Journal of Dermatology” This case report examines a patient with myasthenia gravis, invasive thymoma, and paraneoplastic pemphigus associated with alopecia areata, notably without the usual mucosal involvement.
3 citations
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February 2022 in “Canadian Medical Association Journal” This case report describes a 72-year-old man who developed symptoms of fatigue and cold intolerance after discontinuing his levothyroxine treatment for hypothyroidism six months earlier.
February 2024 in “Internet Journal of Rheumatology and Clinical Immunology” This study examines a diagnostic case of SLE with atypical symptoms linked to thymoma-related multiorgan autoimmunity.
October 2023 in “Journal of the Endocrine Society” In this case report, a shift from Hashimoto's thyroiditis to Graves' disease was observed in a 62-year-old woman, highlighting the rare transformation from hypothyroidism to hyperthyroidism over 20 years, possibly due to changes in antibody activity, according to the researchers.
2 citations
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September 1993 in “PubMed” In this case report, a young man with primary hypothyroidism caused by autoimmune atrophic thyroiditis showed full recovery and normalization of metabolism after levothyroxine treatment.