Non-Motor Symptoms in Myasthenia Gravis: Attributed to T-Cell Clones from Thymoma

April 2013 in “ PubMed ”

Shigeaki Suzuki

alopecia areata autoimmune myasthenia gravis thymoma CD8+ T-cell autoantigens hair follicles

TLDR Abnormal T-cells from thymomas cause non-motor symptoms in some myasthenia gravis patients.

This review explored the non-motor symptoms in patients with autoimmune myasthenia gravis (MG), particularly those with associated thymomas. It was found that abnormal T-cell clones from thymomas contributed to these symptoms. The study highlighted that CD8+ T-cell cytotoxicity against hematopoietic precursor cells and unidentified autoantigens in hair follicles led to conditions like pure red cell aplasia, immunodeficiency, and alopecia areata. Additionally, autoantibody-mediated disorders such as neuromyotonia, limbic encephalitis, myocarditis, and taste disorders were noted. Approximately 25% of MG patients with thymomas experienced at least one non-motor symptom, affecting various organs and ranging from quality of life impairments to potentially lethal conditions.

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Related Research

2 / 2 results

research Non-Motor Symptoms in Myasthenia Gravis: Attributed to T-Cell Clones from Thymoma

2 citations , April 2013 in “PubMed”

Abnormal T-cells from thymomas cause non-motor symptoms in some myasthenia gravis patients.

research Overlooked Non-Motor Symptoms in Myasthenia Gravis

49 citations , November 2012 in “Journal of neurology, neurosurgery and psychiatry”

Non-motor symptoms in myasthenia gravis are common and need early diagnosis for better management.