Non-Motor Symptoms in Myasthenia Gravis: Attributed to T-Cell Clones from Thymoma

April 2013 in “ PubMed ”

Shigeaki Suzuki

alopecia areata autoimmune myasthenia gravis thymoma CD8+ T-cell autoantigens hair follicles

TLDR Abnormal T-cells from thymomas cause non-motor symptoms in some myasthenia gravis patients.

This review explored the non-motor symptoms in patients with autoimmune myasthenia gravis (MG), particularly those with thymomas. It was found that approximately 25% of these patients experienced at least one non-motor symptom, which could range from psychiatric issues like depression and anxiety to autoimmune disorders such as alopecia areata. The study suggested that these symptoms were linked to abnormal T-cell clones from thymomas, with CD8+ T-cell cytotoxicity affecting hematopoietic precursor cells and hair follicles. Additionally, autoantibodies to voltage-gated potassium channels were implicated in various neurological and cardiac disorders. The non-motor symptoms significantly impacted patients' quality of life and could lead to severe conditions.

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Related Research

2 / 2 results

research Non-Motor Symptoms in Myasthenia Gravis: Attributed to T-Cell Clones from Thymoma

2 citations , April 2013 in “PubMed”

Abnormal T-cells from thymomas cause non-motor symptoms in some myasthenia gravis patients.

research Overlooked Non-Motor Symptoms in Myasthenia Gravis

49 citations , November 2012 in “Journal of neurology, neurosurgery and psychiatry”

Non-motor symptoms in myasthenia gravis are common and need early diagnosis for better management.