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This study reported that in mice with rapamycin-induced thymic atrophy, Angelica sinensis promoted thymic cortical regeneration and functional recovery by activating the Wnt/CTNNB1/Foxn1 signaling pathway and improving inflammatory microenvironment, suggesting its potential benefit against immune aging.

This study demonstrates that canonical Wnt signaling is crucial for maintaining thymic epithelial microenvironments in postnatal thymus, possibly by affecting TEC progenitor cells.

This study found that 17beta-estradiol enhanced allergy responses in certain age groups of female mice and inhibited thymus involution and regeneration after contact hypersensitivity.

This study found that despite the persistence of aberrant double-negative T-cells, functional immune-competence was maintained after thymic transplantation in a patient with a rare FOXN1 mutation.

In this study, researchers identified IL18R+ thymus-resident regulatory T cells in mice, demonstrating their unique molecular features and resistance to age- and stress-induced thymus involution, highlighting IL18 signaling's role in Treg migration and retention.

This study found that IL18 signaling plays a crucial role in the homing and retention of mature regulatory T cells in the mouse thymus, primarily by upregulating the chemokine receptor CCR6.

This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.

This study found that deleting FoxN1 in specific thymic epithelial cells disrupted the 3D thymic structure and led to age-dependent formation of 2D epithelial cysts, highlighting FoxN1's critical role in thymic morphogenesis.

This study identified a regulatory element necessary for Foxn1 expression specifically in mouse thymic epithelial cells, crucial for thymus development but not affecting hair follicles.

This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.

This study found that mesenchymal cells from different organs exhibit substantial heterogeneity, with thymic mesenchymal cells particularly adapted for interacting with epithelial and hematolymphoid cells in high-apoptosis environments.

This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.

This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.

This review discusses the relationship between ectodermal alterations and immunodeficiencies, particularly the roles of hyper-IgE syndrome, ectodermal dysplasia, and FOXN1 gene mutations, but it presents no new research findings.

In this study, mouse models of 22q11.2 deletion syndrome showed that growth issues in small embryonic thymuses were linked to mesenchymal cells, which could be corrected by substituting with normal mesenchyme.

In this study, researchers using a mouse model found that the hairlessness in nude mice is likely due to a shared defect in the thymus and skin, not thymic dysgenesis alone.

This study identified key regions and transcription factors, including SIX1 and FOXN1 itself, that regulate Foxn1 expression in thymic epithelial cells and hair follicle cells, offering insights into its transcriptional regulation.

This study found that the postnatal thymus contains a population of mesenchymal stem cells that may help maintain functional thymic microenvironments.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

This study observed that high concentrations of rosemary and thyme extract caused thymic tissue damage, decreased IgM and IgG levels, and fluctuated IL-10 levels in chick embryos, with inflammation signs present despite potential benefits.

In this study, autopsies of children who suffered fatal abuse revealed stress-associated markers like telogen effluvium and thymus involution, which may help pathologists identify chronic abuse cases.

This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.

This review highlights similarities in the development of thymus and skin epidermis, reporting no new results; the authors emphasize shared molecular mechanisms despite different embryonic origins.

This study found that H-Ras activation in aged mouse skin leads to increased dysplasia and progression to in situ squamous cell carcinoma, highlighting an age-linked connection between immune changes, senescence, and cancer risk.

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

This review summarizes recent findings on FOXN1's essential role in thymus and skin biology and discusses emerging therapeutic approaches for immune disorders with athymia, but reports no new clinical results.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This study demonstrated that AIRE-deficient rats exhibit key symptoms of APECED, making them a relevant model for exploring potential treatments.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

In this study, thymosin beta4 was found to stimulate hair growth in normal rats and mice by affecting key processes in the hair follicle cycle, such as stem cell migration and extracellular matrix remodeling.