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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

Lactate production is important for activating hair growth stem cells.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

Oestrogens are key for bone growth during puberty in both boys and girls.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Wnt ligands are crucial for hair growth and repair.

Current treatments for alopecia show no significant long-term benefits.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Understanding hair follicle anatomy helps diagnose hair disorders.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Probiotic bacteria improved skin and hair health in aged mice.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

New topical antifungals and delivery systems are improving treatment for fungal skin infections, but patient education and prevention are key.