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The researchers concluded that their new reconstructed human epidermis model from plucked hair follicle-derived keratinocytes offers a safer and simpler alternative to traditional skin-derived models for studying epidermal function.

This paper proposes a model integrating regulatory T cells and mesenchymal stem/stromal cells to enhance understanding of peripheral immune tolerance, suggesting their combined roles in immune regulation, autoimmunity pathophysiology, and potential MSC-based therapies.

This study found that both intradermal BCG vaccine and intralesional triamcinolone acetonide were similarly effective for treating patchy alopecia areata, though intralesional triamcinolone was preferable due to fewer side effects associated with BCG vaccine.

The researchers reported that hair follicle development and commensal microbe colonization promote the accumulation of regulatory T cells in neonatal skin, with the Ccl20-Ccr6 pathway playing a key role in this process.

In this study, researchers developed a biomimetic anti-inflammatory nanosystem (MM-CEP/NLCs) that significantly reduced the severity of acute lung injury in vivo by targeting and accumulating in lung inflammation sites, showcasing its potential for treating inflammation.

This study reports that erythematous, infiltrated plaques can develop in patients receiving subcutaneous heparin therapy, indicating a possible delayed hypersensitivity reaction to heparin or its constituents.

This review investigates laser-induced Koebner-related reactions and highlights how different laser types, targets, and session frequencies affect the development of these skin responses, particularly in individuals with darker skin phototypes.

The study found that adipose-derived mesenchymal stem cells obtained via laser-assisted liposuction with selective photo-stimulation are comparable in differentiation potential and tumorigenic risk to those from conventional liposuction for cell therapy applications.

This study found that MAPK/ERK signaling plays a key role in driving tissue regeneration in spiny mice and suggests potential for reversing fibrosis to promote regeneration in mammals.

This review explores the use of skin penetration enhancers like Transcutol® in various formulation systems, discussing their mechanisms and effectiveness in improving transdermal drug delivery without breaching the skin.

This study provides detailed macro and microscopical observations of Tridax procumbens Linn. leaf, which could aid in its identification.

Aging weakens sweat glands due to reduced support from immune cells, but treatments may help restore function.

This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.

This study found that applying topical thymidine dinucleotide (pTT) to newborn mice before UV exposure delayed and reduced melanoma development compared to untreated controls.

In this study, researchers developed a three-dimensional ultrastructural analysis tool using serial block-face scanning electron microscopy to reveal detailed nerve networks and muscle structures in human skin tissues, demonstrating the technique's potential to study structural changes in aging or disease.

This study found widespread localization of parathyroid hormone-related protein in normal and cancerous canine tissues, suggesting a potential physiological role as a paracrine or autocrine factor.

Norfolk Terriers have a genetic skin defect causing scaling and blisters due to a keratin issue.

This study observed that thymol from Origanum marjoram essential oil significantly promoted hair regrowth and reduced inflammation in cyclophosphamide-induced alopecia in rabbits, with effects that were comparable to or exceeded those of betamethasone, highlighting its potential as a safer treatment alternative.

This study found that CTCF is crucial for proper skin and hair follicle development in mice, affecting keratinocyte differentiation and gene expression in keratin loci.

In this study, researchers observed that intractable pruritus in anterior chest keloid lesions is linked to increased intraepidermal nerve fibre density and elevated expression of substance P, without differences in Langerhans cells across different keloid regions.

This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.

This study found that in a human skin organ culture model of pemphigus vulgaris, split formation led to significant upregulation of IFNγ and TNFα-related genes, indicating secondary effects from mechanical stress, not direct changes from autoantibodies.

In this study using a rat full-thickness burn model, the amnion bilayer dressing showed better healing and skin recovery than the standard protocol, including quicker complete healing and restored skin appendages.

This study shows that microdiffraction experiments reveal structural layers in keratinous tissues, each with different keratin types, potentially explaining their dual role as mechanical support and chemical barriers.

In this study, researchers developed thermoresponsive nanogels that effectively penetrate hair follicles and release a model drug when triggered by temperature, demonstrating greater penetration for medium to large nanogels (300–500 nm) compared to smaller ones.

An 8-year-old girl with vitiligo developed extra hair growth on her knee after using tacrolimus ointment.

This study found that combining liposuction with diode laser ablation was effective in treating axillary osmidrosis, with high patient satisfaction and no significant complications reported over a 10-month follow-up period.

This study examined the effectiveness of using intradermotherapy, with or without microneedling and topical solutions, in reducing hair loss among men with androgenetic alopecia, though results are not reported in the abstract.

A woman had a severe skin reaction from the drug imiquimod, used for skin cancer, highlighting the need for awareness of rare but serious side effects.