5 citations
,
September 2024 in “Journal of Clinical Medicine” This article reviews the pathophysiology of chemotherapy-induced alopecia and reports that scalp cooling can reduce hair loss by 50% in patients with early breast cancer receiving chemotherapy, without compromising survival or increasing scalp metastasis risk.
3 citations
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May 2011 in “Medical Hypotheses” This article proposes that transnasal evaporative cooling could advance understanding of various physiological phenomena, but reports no new clinical results; potential research directions are suggested for this concept.
February 2026 in “International Journal of Molecular Sciences” This review discusses the potential benefits of hyperthermia in cancer therapy, combined with natural compounds, to enhance treatment efficacy and reports no new clinical results.
1 citations
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July 2025 in “Advanced Science” This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.
1 citations
,
August 2023 in “Composites Part B: Engineering” In this study, researchers developed a composite electrospun wound dressing containing strontium zinc silicon bioceramics, which significantly activated hair follicle stem cells and promoted hair follicle and capillary regeneration in deep burn wounds, suggesting a promising approach for burn wound healing.
1 citations
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May 2006 in “Expert Opinion on Therapeutic Patents” This review summarizes 19 patents filed since 2000 for treating or preventing chemotherapy-induced alopecia, but reports no new clinical findings.
9 citations
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November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
This study found that liquid nitrogen cryotherapy significantly improved alopecia areata in 27.4% of treated patients after six weeks, with no association between treatment efficacy and factors like age or gender.
69 citations
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February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
February 2018 in “Medicine - Programa De Formación Médica Continuada Acreditado” This review discusses current and emerging treatments for androgenic alopecia, noting that minoxidil and finasteride are the only FDA-approved options, while other methods lack comparable evidence of efficacy.
60 citations
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June 2017 in “IOSR Journal of Pharmacy (IOSRPHR)” This review highlights the chemical components and various potential health effects of Daucus carota but reports no new experimental results.
25 citations
,
December 2001 in “Expert Opinion on Pharmacotherapy” This review discusses the therapeutic potential of potassium channel openers for various conditions, but notes that their clinical role is not yet fully established.
119 citations
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June 2005 in “Journal of Molecular and Cellular Cardiology” This article reviews the therapeutic potential of potassium channel openers for various conditions related to metabolic distress but does not report new clinical results; it emphasizes the need for further research.
4 citations
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August 2023 in “Varna Medical Forum” This article explores the therapeutic potential of TECAR therapy for physiotherapy, highlighting its non-invasive nature and ability to provide analgesic, anti-inflammatory, and tissue healing effects across various conditions with minimal side effects when applied correctly.
September 2025 in “Medical Materials Research” This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.
April 2016 in “Journal of Urology and Nephrology Open Access” This abstract discusses treatment options for benign prostatic hyperplasia and provides no new clinical results.
March 2026 in “Frontiers in Cell and Developmental Biology” This review synthesizes evidence that photobiomodulation may provide robust symptomatic relief for knee osteoarthritis but indicates its potential for structural regeneration remains speculative and needs further long-term validation.
January 2026 in “Frontiers in Materials” This review discusses the potential of metal organic frameworks for drug delivery in wound treatment, highlighting their unique properties and recent research advancements, but reports no new clinical results.
January 2025 in “International Journal of Advanced Biochemistry Research” This research proposes to investigate the incidence of skin diseases in dogs from North-eastern India linked to deficiencies in alpha-linolenic and linoleic acids, as these essential fatty acids have anti-inflammatory and immunomodulatory benefits potentially aiding inflammatory skin disease therapy.
39 citations
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April 2020 in “IntechOpen eBooks” The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.
1 citations
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June 2023 in “Ethnobotany research and applications” This review examined the medicinal properties of the Ziziphus plant species, highlighting their traditional use in treating various conditions and their bioactive compounds with potential anticancer, antimicrobial, and anti-diabetic effects. The authors concluded that Ziziphus species, particularly jujube, have promising pharmacological activities warranting further investigation.
January 2025 in “Journal of Medical Biochemistry” This review explores the roles of superoxide dismutases in cellular processes and cancer, highlighting the potential of SOD mimetics in enhancing cancer treatment strategies, but it reports no new clinical findings.
3 citations
,
January 2024 in “Signal transduction and targeted therapy” This study presents a detailed overview of lymphatic vessel development and highlights the role of abnormal lymphangiogenesis in various diseases, suggesting that targeting lymphangiogenic factors may improve treatment strategies.
14 citations
,
January 2013 in “Journal of Cutaneous Medicine and Surgery” This study describes permanent scalp alopecia in patients receiving chemotherapy, radiation, or both, and highlights the need for further research to identify causative factors and mitigation strategies.
85 citations
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April 2007 in “Dermatologic Clinics” This article reviews drug-induced hair changes, highlighting that while many drugs are occasionally linked to hair loss, this connection has been conclusively established for only a few, and such hair loss is typically reversible.
30 citations
,
June 2014 in “Seminars in Immunology” This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.
159 citations
,
September 2001 in “European Journal of Cancer Care” This literature study reviews the consequences of hair loss due to chemotherapy and nursing care interventions but reports no new clinical results.
39 citations
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January 1994 in “European Journal of Cancer” In this study, scalp hypothermia with the Theracool™ cooling machine was largely ineffective for preventing alopecia in breast cancer patients undergoing a chemotherapeutic regimen including cyclophosphamide and anthracyclines.
37 citations
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October 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This literature review reported that scalp hypothermia significantly decreases the occurrence of chemotherapy-induced alopecia, increasing effectiveness by 2.7-fold in controlled clinical trials and 3.9-fold in randomized trials, and highlighted a need for standard guidelines for its use.
3 citations
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January 2011 in “Wspolczesna Onkologia-Contemporary Oncology” Scalp hypothermia can prevent chemotherapy-induced hair loss but is not suitable for all patients, and more research is needed to improve prevention methods.