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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

We need more research on human hair follicle pigmentation, not just mouse models.

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Systemic treatment is necessary for tinea capitis in children, with griseofulvin preferred for Microsporum infections.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Most COVID-19 patients in hospitals have androgenetic alopecia, more in men, suggesting a link between androgen sensitivity and severe COVID-19 symptoms.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Keratin from human hair shows promise for medical uses like wound healing and tissue engineering.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

Red light therapy at 655 nm significantly improved hair growth in men with hair loss.

The conclusion is that the increasing use of drugs for lifestyle reasons is a complex issue influenced by corporate profit, consumer behavior, and the medicalization of everyday life, with potential negative effects on personal well-being.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.