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This study demonstrated that an ethanol extract of Connarus semidecandrus Jack showed potential anti-androgenic alopecia effects in a testosterone-induced model, suggesting a possible treatment option for hair loss.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.

This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.

In this study, 150 kHz electromagnetic radiation reduced the number and size of follicular cysts in a rat model of polycystic ovary syndrome without causing significant morphological damage to developing follicles.

In this study using a PCOS mouse model with added stress, researchers observed that combining corticosterone with dihydrotestosterone partially supported the hypothesis of behavioral changes, aligning with depression and anxiety-linked symptoms in women with PCOS.

This study found that melatonin implants at specific times of the year may increase cashmere production in young Australian cashmere goats by altering their growth cycles.

In this review, extensive analysis using conditional mutant mice revealed that androgen and Wnt signals play crucial roles in the development and function of male external genitalia and erectile tissue, while also exploring various regulatory factors involved in their pathogenesis.

This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.

This review discusses the potential mechanisms by which androgens may elevate blood pressure, particularly through impacts on the renin-angiotensin system, but reports no new experimental results.

This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.

In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.

This article discusses the potential role of probiotics and synbiotics in managing hirsutism through insulin resistance but reports no new clinical results, calling for further research.

This narrative review discusses the mixed and evolving evidence regarding glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and their influence on erectile dysfunction in men with type 2 diabetes and obesity, highlighting potential benefits and concerns yet to be clarified.

This study updates guidelines for evaluating and managing male infertility, including revised testing recommendations for Y-chromosome microdeletions, use of pelvic MRI, and testicular sperm in nonazoospermic males.

Adding bentonite clays to goat diets increased milk yield, periwinkle shell improved chicken egg production, and vaccination increased muscle area and carcass yield in calves.

This review discusses the role of DHEA in intracrinology, highlighting its impact on breast and prostate cancer treatment and potential as a menopause therapy, but reports no new research findings.

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

This study found that dutasteride may help prevent enteric neuronal damage in an animal model of Parkinson's disease, highlighting its potential for drug repurposing to address neuroinflammation.

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.

This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.

The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.

This study reported that certain newly synthesized steroidal derivatives showed stronger inhibitory activity against the 5α-reductase enzyme than finasteride in hamsters, suggesting their potential as enzyme inhibitors.

In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.

This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.

This study reports that five new progesterone derivatives demonstrated inhibitory activity against the 5α-reductase enzyme and binding affinity for the androgen receptor in an in vitro hamster model.

In studying wild meerkats, researchers observed that matriarchs with high androgen levels during late gestation exhibited increased dominance and aggression, affecting both their behavior and their offspring's aggression.

This review discusses the use of antiandrogens like flutamide and its derivatives in prostate cancer treatment and highlights the need for next-generation antiandrogens for improved efficacy; it reports no new clinical results.

This review discusses the role of hormones in acne vulgaris and highlights the need for further research on their mechanisms of action; it reports no new clinical results.

This review discusses the rationale for targeting 5α-reductase isoenzymes in prostate cancer prevention and treatment, highlighting the potential benefits of using inhibitors like dutasteride and finasteride but reports no new experimental results.