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This review discusses androgen therapy in adolescents, detailing current practices and noting the limited use of commercially available testosterone or dihydrotestosterone formulations; no new results are reported.

This consensus document discusses guidelines for gender-affirming hormone therapy in India, offering recommendations based on a review of existing evidence and expert input, without reporting new clinical results.

This review discusses the structure and function of the testes in male reproduction and development, noting the complex hormonal regulation within the hypothalamic-pituitary-gonadal axis but reports no new clinical results.

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

This study found that Grateloupia elliptica extract may help treat hair loss by promoting dermal papilla cell proliferation, inhibiting 5α-reductase, and reducing inflammation in various cell types.

In this study, male rats with spinal cord injury that received either E2 or DHT supplementation both showed restored expression of respiratory neuroplasticity following acute intermittent hypoxia, with E2 also enhancing overall breathing recovery.

This study suggested that moxibustion treatment before or at the early stage of diminished ovarian reserve in rats may improve ovarian function by modulating androgen balance, though its effects differ across intervention timings.

In this review, the authors highlight that drugs promoting androgenic activity or inhibiting estrogenic activity may unmask or worsen androgenetic alopecia in genetically predisposed individuals, indicating the need for careful management in clinical settings.

This review outlines the complexities of understanding DHT biosynthesis and metabolism in the human prostate and reports no new findings, emphasizing the need for further research into the pathways involved.

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.

This review discusses the skin's role in producing hormones and related substances, highlighting their potential in homeostasis and disease management, and reports no new clinical findings.

This article discusses the challenges in diagnosing female androgen insufficiency syndrome due to unreliable testosterone measurement methods but notes symptom improvement with testosterone therapy, emphasizing the need for women-specific formulations and safety guidelines.

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

This study found that penile and clitoral differentiation in mice is influenced by androgen exposure, with penile features developing postnatally requiring prenatal and ongoing androgen presence.

In this study, researchers developed a sensitive LC–MS–MS assay to measure 3α-androstanediol levels in rat plasma and observed that testosterone raises these levels via a 5α-reductase pathway.

In this study, nandrolone decanoate treatment in rats caused persistent diestrus and altered steroid receptor expression and sex hormones, especially at higher doses, with partial reversibility at lower doses over time.

This study found that a self-assessed modified Ferriman-Gallwey score of 10 or higher indicates excess body hair, and suggests androstenedione measurement should accompany testosterone when evaluating hyperandrogenism.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

This study in mice found that topical pumpkin seed oil promoted hair growth and could be a promising alternative treatment for male pattern alopecia.

This study found that both a proprietary ultrahigh-pressure extract and a hexanic extract of saw palmetto showed comparable inhibition of 5α-reductase, suggesting similar potential for managing symptoms of benign prostatic hyperplasia.

This study found that prolonged use of finasteride in women led to altered levels of sex steroids, DNA damage, and increased menstrual bleeding, suggesting adverse health effects without clear benefits for androgenetic alopecia treatment.

This study found that high prepubertal and pubertal androgen levels, originating from both adrenal and gonadal secretion, were negatively associated with adult height outcomes in males with Silver-Russell syndrome.

In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.

In this study, researchers found that exosome-like nanoparticles isolated from Polygoni Multiflori Radix can promote hair growth in mice by modulating androgen signaling and gene expression, outperforming Minoxidil in testosterone-induced conditions.

LMWP-PDGFA shows promise for improving hair health and treating hair loss with fewer side effects.

This animal study observed that dihydrotestosterone increased arterial stiffness and decreased estrogen receptor expression in female mice, potentially impacting cardiovascular health in contexts of androgen use.

This study developed a microneedle system using black phosphorus nanosheets and baicalin for treating androgenetic alopecia, finding it effectively enhanced drug penetration and follicular targeting while showing synergistic efficacy and safety in preclinical tests, including in vivo model efficacy against testosterone-induced hair loss.

This review discusses the causes and recommended clinical investigations for postmenopausal hyperandrogenism, highlighting the role of androgen excess in symptoms like hirsutism and its association with metabolic disorders.

This study found that the ethanolic extracts of G. glabra and Z. mauritiana roots did not prevent androgenic alopecia in a testosterone-induced animal model.