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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

The document concludes that more inclusive research involving the transgender community is needed, especially on the neovaginal microbiome of trans women.

Dermatologists should address erectile dysfunction in patients with skin conditions to improve their quality of life.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.

Rothmund-Thomson syndrome type 2 can cause chronic, poorly healing wounds.

Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.

Consider benefits and risks of new alopecia treatments for safety.

5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.

Treatment restored normal sexual characteristics and blood condition in a patient with testicular cancer.

An 8-year-old boy with Recklinghausen's Disease shows various symptoms and is from a family with close genetic ties.

Imaging helps detect adrenal gland issues and monitor treatment in congenital adrenal hyperplasia, and can identify tumors affecting fertility.

Finasteride may cause lasting sexual and mental health issues, and genetic screening could help prevent them.

Doctors are preparing to potentially perform uterus transplants in transgender women, considering technical, hormonal, and ethical factors.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Always consider xanthomatous hypophysitis before deciding on pituitary surgery.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

A patient grew extra hair on their ears after treatment for testicular cancer, possibly due to hormonal changes or genetics.

Low testosterone does not prevent prostate cancer in men with type 1 diabetes.

The virus was not found in the semen and urine of a man who tested positive for COVID-19.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Finasteride can reduce fertility in some men, but stopping it increases sperm count.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

Researchers isolated a new type of stem cell from mouse skin that can renew itself and turn into multiple cell types.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.