Xanthomatous Hypophysitis: Always Think Twice Before Pituitary Resection

    November 2022 in “ Journal of the Endocrine Society ”
    Vipawee Panamonta, Arunee Singhsnaeh, Sira Korpaisarn
    Image of study
    TLDR Always consider xanthomatous hypophysitis before deciding on pituitary surgery.
    A 47-year-old male with symptoms of low libido, hair loss, increased thirst, and nocturia was initially referred for pituitary adenoma resection. Laboratory tests revealed hypopituitarism and central diabetes insipidus (DI), and an MRI showed an enlarged pituitary gland without stalk thickening. The patient's symptoms and MRI findings did not align, prompting a biopsy instead of resection. The biopsy revealed xanthomatous hypophysitis, characterized by clusters of foamy macrophages and positive immunohistochemistry for CD3, CD20, CD138, and CD68, but negative for IgG4. The patient was treated with hormonal replacement therapy, avoiding unnecessary surgery. This case highlights the importance of considering xanthomatous hypophysitis, a rare condition with only 36 reported cases, as a differential diagnosis in pituitary disorders, especially when clinical and imaging findings do not match.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair Loss Results After 8 Months of Dutasteride

      in Progress Pictures  230 upvotes 1 month ago
      The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

      community Hair Loss Due To Chlorine and Hard Metals In Water?

      in Research/Science  1 upvotes 2 months ago
      Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

      community Hair Loss Treatments and Hair Transplant

      in Progress Pictures  4 upvotes 2 months ago
      The user is experiencing hair loss and is using oral finasteride, considering adding RU58841 and microneedling, and planning a hair transplant. They are seeking advice on whether to wait for treatment results or proceed with the transplant.

      community Hair loss steps, guide to beginners or anyone experiencing hair loss

      in Treatment  1 upvotes 2 months ago
      The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 2 months ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

    Similar Research

    5 / 1000+ results
      COVID-19 and Hypopituitarism

      research COVID-19 and Hypopituitarism

      15 citations, August 2021 in “Reviews in endocrine and metabolic disorders”
      COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.
      Endocrinology

      research Endocrinology

      April 2023 in “Clinical Chemistry and Laboratory Medicine”
      The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.
      The Eye and the Skin in Endocrine Metabolic Diseases

      research The Eye and the Skin in Endocrine Metabolic Diseases

      10 citations, December 2015 in “Clinics in Dermatology”
      Diabetes can lead to blindness and skin problems, and managing blood sugar and blood pressure is crucial to prevent these complications.