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Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This review discusses the use of nanomaterials in hair cosmetics and treatments and reports no clinical results, highlighting their potential to improve the efficacy and safety of active compounds.

This study conducted in situ tensile loading experiments with atomic force microscopy to observe how conditioning treatments affect the tensile response of virgin, chemically damaged, and mechanically damaged Caucasian hair.

This study analyzed gray hair, revealing that it differs from pigmented hair in follicular activity, oxidative balance, and structure, impacting coloring processes and necessitating adapted techniques to maintain hair quality.

This study found that fibroblasts from mature skin showed significantly reduced mechanical force production compared to young skin fibroblasts, suggesting age-related changes in cellular mechanical properties.

This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.

This study used cryoelectron microscopy to unveil the structure of LPA-bound human LPAR6, revealing unique ligand binding and recognition modes distinct from LPAR1, which may aid in designing targeted compounds for hair loss and cancer.

This scoping review suggests that physiological differences in skin structure may affect how individuals with different skin tones respond to pressure ulcer development, emphasizing the need for targeted prevention strategies.

In this study, targeted overexpression of the BMP receptor ALK2 in mouse hair follicle stem cells altered follicle structure and impaired cutaneous wound healing.

This narrative review highlights the distinct needs of pediatric hair care, emphasizing gentler formulations due to differences in children's hair physiology, structure, and barrier function, and calls for targeted regulations and research due to limited safety evidence.

This review highlights concerns around premature greying in children, detailing possible links to nutritional deficiencies and other health issues, and emphasizes that structured evaluation and targeted treatment may aid in reversing the condition.

This article discusses the potential for targeted therapies in hair loss by exploring inflammatory and cytokine-mediated processes, but it presents no new clinical results.

This review reports that the unique tunnel structures in advanced hidradenitis suppurativa impair quality of life and resist biological therapy, with their formation involving complex cellular and molecular interactions, including microbial dysbiosis, all contributing to ongoing inflammation and scarring.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

This review highlights the potential of PROTAC technology in drug discovery for previously undruggable targets, particularly in cancer therapy, while emphasizing the urgent need to discover more E3 ligase recruiters to optimize targeted protein degradation.

Minoxidil treatment in mice preserved the integrity of elastic lamellae and improved arterial biomechanical properties, especially in females, suggesting it could be an anti-arterial aging agent potentially suitable for female-targeted therapies.

This study found that citric acid treatment can significantly improve the structural integrity and mechanical properties of chemically treated hair, reducing damage by increasing keratin crosslinking density and decreasing crystallized calcium soaps, with varying effectiveness depending on the type of chemical treatment.

This review explores the potential role of caveolin-1 in cicatricial alopecia, particularly frontal fibrosing alopecia, and discusses possibilities for targeted therapies without providing new research results.

This study outlines a framework for hair longevity that emphasizes prevention and integrative management of androgenetic alopecia by proposing a multi-targeted approach combining treatments, nutrition, and lifestyle changes.

In this study, researchers observed that cosmetic peroxide bleaching causes oxidative damage and protein loss in human hair, not only affecting the cuticle but also deeper cortical structures, correlating with bleaching severity.

This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.

This review outlines recent progress in CRISPR/Cas9 genome editing, discussing its structure, mechanisms, and the use of genetic, chemical, and physical strategies to enhance precision and reduce off-target effects despite some persistent challenges for clinical application.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.

This study found that genetic ablation of Tet genes in mice led to changes in hair structure and keratin gene expression, indicating a role for Tet-mediated 5hmC DNA oxidation in hair follicle development and cycling.

In this study, researchers found distinct gene expression patterns in Standardbred trotters capable of racing barefoot, suggesting a genetic basis for hoof strength and identifying specific genes involved in hoof biology, which could enhance equine performance and wellbeing through targeted genetic research.

In this study, researchers developed a biocompatible, ROS-responsive hydrogel to deliver miR-665 locally, effectively reducing inflammatory signaling and promoting hair follicle regeneration in an alopecia areata mouse model, offering a promising approach for targeted treatment.

This study found that a newly developed biocompatible hydrogel, responsive to reactive oxygen species, enabled targeted delivery of miR-665, significantly promoting hair regeneration and reducing T-cell infiltration in a mouse model of alopecia areata, suggesting a promising strategy for treating this condition.

This study reported significant transcriptomic changes in keratinocyte and immune cell populations in a mouse model with EGFR-deficient epidermis, suggesting possible targets for mitigating adverse skin events in EGFR-targeted cancer therapy.

This review examined the role of organoid technology in modeling genetic diseases, highlighting its promise for understanding disease pathology and developing tailored treatments by integrating genetic insights with advancements in regenerative medicine and biological engineering.