159 citations,
October 2015 in “Science Advances” Blocking JAK-STAT signaling can lead to hair growth.
127 citations,
June 2008 in “British Journal of Clinical Pharmacology” Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
110 citations,
August 2016 in “Drugs” Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.
86 citations,
August 2011 in “Toxicological sciences” TCDD speeds up skin barrier formation by increasing certain gene expressions.
84 citations,
April 2013 in “Applied Microbiology and Biotechnology” Mannosylerythritol lipids are good for skin and hair care products.
74 citations,
June 2018 in “Cell death and disease” Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.
71 citations,
January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology” mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.
53 citations,
October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
43 citations,
July 2014 in “Experimental Dermatology” Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.
38 citations,
March 2017 in “Expert Opinion on Investigational Drugs” Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.
35 citations,
May 2012 in “Expert Opinion on Pharmacotherapy” The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.
31 citations,
January 2015 in “Journal of The American Academy of Dermatology” Prostaglandin F2α analogs show promise for treating certain types of hair loss but need more research for other skin conditions.
30 citations,
December 2018 in “International Journal of Biological Macromolecules” Chitosan and surface-deacetylated chitin nanofibers may help treat hair loss.
29 citations,
January 2010 in “Journal of oleo science” MEL-A from soybean oil can boost fibroblast and papilla cells, potentially aiding hair growth.
23 citations,
February 2021 in “Journal of Endocrinological Investigation” Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.
20 citations,
February 2017 in “International Journal of Dermatology” Honokiol helps protect skin from damage and aging caused by cigarette smoke.
19 citations,
April 2015 in “European Journal of Pharmacology” Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.
18 citations,
November 2020 in “Frontiers in Cell and Developmental Biology” Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.
18 citations,
January 2019 in “Experimental Dermatology” Certain cells outside the hair follicle's bulge area can quickly regenerate damaged hair follicles, potentially helping to reduce hair loss from cancer treatments.
14 citations,
July 2016 in “Pediatric Dermatology” A 9-year-old girl with alopecia areata had successful hair regrowth using bimatoprost after other treatments failed.
12 citations,
October 2017 in “Radiation Research” mTORC1 signaling needed for quick hair follicle recovery after radiation damage.
10 citations,
August 2018 in “Experimental Dermatology” Decorin helps hair cells grow and move, and keeps hair growth phase going in mice.
10 citations,
February 2015 in “Clinics in Dermatology” The document concludes that changes in eyelashes and eyelid skin can indicate various local and systemic diseases.
8 citations,
June 2021 in “International Journal of Molecular Sciences” Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.
7 citations,
April 2017 in “Dermatologic surgery” Hyaluronic acid fillers and combination treatments significantly improve facial defects from autoimmune diseases and are well-tolerated.
6 citations,
January 2020 in “International Journal of Biological Sciences” Septin4 helps kill colon cancer cells by working with the protein BAX.
6 citations,
January 2013 in “Experimental dermatology” Bimatoprost increases hair growth in mice without breaking down into other substances.
5 citations,
December 2018 in “Biological & Pharmaceutical Bulletin” Norgalanthamine helps hair cells grow by activating certain pathways related to hair growth.
4 citations,
August 2017 in “Journal of cutaneous pathology” An 8-year-old girl had a rare, benign skin tumor on her forehead.
4 citations,
December 2015 in “Journal of Medicinal Plants Research” A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.