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Glossary Sweet's syndrome

rare inflammatory condition with fever and painful skin lesions

Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition characterized by the sudden onset of fever, elevated white blood cell count, and tender, red or purple skin lesions, typically on the face, neck, and upper limbs. It is often associated with underlying conditions such as infections, malignancies, or autoimmune diseases, and can be treated effectively with corticosteroids.

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research SWEET SYNDROME: AN UNUSUAL PRESENTATION OF CHRONIC GRANULOMATOUS DISEASE IN A CHILD

24 citations , June 1999 in “The Pediatric Infectious Disease Journal”

In this case report, a 2-year-old boy initially diagnosed with Sweet syndrome was later found to have chronic granulomatous disease, highlighting the importance of considering CGD in unusual cases of Sweet syndrome.

research Sweet Syndrome as the Presenting Symptom of Relapsed Hairy Cell Leukemia

12 citations , December 2002 in “Archives of Dermatology”

This case report describes a 49-year-old woman with Sweet syndrome who experienced complete resolution of skin lesions after a prednisone treatment regimen.

research Cryptococcoid Sweet syndrome: A case report and literature review

February 2024 in “International Journal of Dermatology”

This study outlines a rare case of cryptococcoid Sweet syndrome linked to hydralazine use and previous cocaine exposure, emphasizing the importance of recognizing unique histopathological features such as multiple positive autoantibodies and mucosal involvement to ensure timely diagnosis and treatment.

research Clouston syndrome associated with eccrine syringofibroadenoma

18 citations , June 2014 in “Anais Brasileiros de Dermatologia”

This case report describes a patient with Clouston Syndrome who developed eccrine syringofibroadenoma, marking only the fourth such association documented in existing literature.

research Hand-Foot and Stump Syndrome to Sorafenib

45 citations , January 2007 in “Journal of Clinical Oncology”

This case report identifies hand-foot and stump syndrome as a potential side effect of sorafenib therapy in a 47-year-old man with a leg amputation.

research Classic Sweet sydrome: A case report

August 2018 in “Journal of The American Academy of Dermatology”

A 54-year-old man with painful skin blisters and fever was diagnosed with Sweet syndrome and successfully treated with corticosteroids.

Immunohistochemical Insight Into the Association Between the Collapse of Immune Privilege in the Sweat Gland and Syringotropic Immune Cell Infiltrates in Collagen Diseases

research 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases

September 2017 in “Journal of Investigative Dermatology”

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

research Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx

December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study found that knocking out the Hars2 gene in mouse cochlear hair cells led to mitochondrial dysfunction and ROS stress, resulting in progressive hearing loss and differential effects on inner and outer hair cells.

research Cutaneous reactions to recombinant cytokine therapy

105 citations , September 1995 in “Journal of The American Academy of Dermatology”

This review discusses the use of recombinant cytokines as therapeutic agents in clinical settings and describes the range of cutaneous complications associated with their use, including both minor and severe skin reactions.

research Helicobacter pylori infection and skin disorders

25 citations , July 2014 in “Hong Kong medical journal”

This review discusses potential associations between Helicobacter pylori infection and various skin diseases but reports no new clinical findings; more research is needed to clarify these links.

Review of Aseptic Neutrophilic Dermatoses

research REVIEW OF SO-CALLED ASEPTIC NEUTROPHILIC DERMATOSES

17 citations , August 1983 in “Australasian Journal of Dermatology”

The review says skin conditions with sterile pustules need more research for better treatments.

research Skin manifestations associated with systemic diseases – Part I

11 citations , September 2021 in “Anais Brasileiros de Dermatologia”

This article reviews how skin manifestations can aid in diagnosing various systemic diseases, focusing primarily on their association with rheumatologic conditions while also addressing vascular, granulomatous, and other disease impacts, aiming to provide dermatologists with practical diagnostic insights.

research Cutaneous drug reactions

1 citations , January 2010 in “Elsevier eBooks”

Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

research Cutaneous Reactions to Drugs

3 citations , July 2017 in “Elsevier eBooks”

This article reviews the identification and assessment of cutaneous drug reactions, emphasizing the importance of early recognition and the need for accurate diagnosis to prevent serious complications; it reports no new clinical results.

research ASSOCIATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND CHRONIC GRANULOMATOUS DISEASE IN ADULTS: REPORT OF 2 CASES

May 2025 in “The Journal of Rheumatology”

This report describes two cases where female patients with chronic granulomatous disease developed manifestations of systemic lupus erythematosus, highlighting a rare association that may influence clinical evaluation and treatment planning.

research Circumferential acute limited exanthematous pustulosis

August 2018 in “Journal of The American Academy of Dermatology”

A 16-year-old girl's skin rash was likely caused by an infection and improved with topical steroids.

research Temporal triangular alopecia and a review of 52 past cases

56 citations , March 2010 in “Journal of Dermatology”

This review provides a synopsis of 53 cases of temporal triangular alopecia, noting its frequent detection in early childhood and potential association with congenital diseases, but it reports no new clinical findings.

research Structure and Development of the Skin and Cutaneous Appendages

1 citations , July 2016 in “Elsevier eBooks”

Understanding skin structure and development helps diagnose and treat skin disorders.

research Androgen effects on the skin

July 2015 in “Cambridge University Press eBooks”

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

research Clouston’s Syndrome-A Case Report

March 2021 in “Annals of King Edward Medical University”

This report details a case of a 3-year-old child with Clouston syndrome, a rare inherited disorder affecting nails, skin, and hair, highlighting the need for supportive management due to the absence of treatment options.

research Clouston’s syndrome: a rare case report

August 2020 in “International Journal of Research in Dermatology”

This report describes a 23-year-old male with Clouston’s syndrome, characterized by nail abnormalities, palmoplantar skin thickening, anodontia, and androgenic alopecia, highlighting the need for supportive management due to the lack of a definitive treatment.

research A four generation hidrotic ectodermal dysplasia family: an allelic variant of Clouston syndrome?

9 citations , October 1995 in “Clinical Dysmorphology”

This study described a Scottish family with hidrotic ectodermal dysplasia featuring variable symptoms such as hypo/oligodontia, thin hair, and heat tolerance, and concluded they exhibited overlapping traits with Clouston syndrome.

research A novel pathogenic variant of NECTIN4 gene in a child with ectodermal dysplasia-syndactyly syndrome

January 2023 in “Indian dermatology online journal”

This case report describes a novel NECTIN4 gene mutation linked to ED-syndactyly syndrome 1 in a young girl, contributing to the understanding of this rare ectodermal dysplasia.

research Dietary Patterns and Metabolic and Hormonal Parameters in Women with Suspected PCOS

April 2025 in “Journal of Clinical Medicine”

In this study, women with suspected PCOS who reduced their intake of sweets, fatty red meat, and alcohol for over 6 months showed significantly lower total testosterone levels compared to those who did not, highlighting the benefit of targeted dietary changes on hormonal profiles.

research Cylindroma as Tumor of Hair Follicle Origin

57 citations , February 2006 in “Journal of Investigative Dermatology”

Cylindromas likely originate from hair follicle stem cells, not sweat glands.

research Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

53 citations , October 1984 in “Endocrine reviews”

This review highlights that idiopathic hirsutism is characterized by local hyperandrogenization affecting hair growth, without other signs of hyperandrogenism, and shows no new results; racial differences in prevalence are noted but not in androgenic steroids.

research Expression and localization of Artemis serine 516 phosphorylation in human scalp skin

5 citations , August 2012 in “Experimental Dermatology”

In this study, Ser516 phosphorylation of Artemis was found predominantly in the outer root sheath keratinocytes of hair follicles, suggesting a role in regulating human epidermal appendages.

Acquired Uncombable Hair Syndrome in a 39-Year-Old Woman

research Acquired Uncombable Hair

6 citations , August 1993 in “Archives of Dermatology”

This article describes the first documented case of acquired uncombable hair syndrome in a 39-year-old woman, contributing to the understanding of this rare condition.

research Myeloma, Paraproteinemias, and the Skin

54 citations , January 1986 in “Medical clinics of North America/The Medical clinics of North America”

This study reviewed pathology reports of patients with multiple myeloma and found that skin biopsies commonly show graft-versus-host disease, drug-related lesions, and Sweet's syndrome, especially related to transplantation timing.

research Skin Development and Disease: A Molecular Perspective

15 citations , July 2024 in “Current Issues in Molecular Biology”

This narrative review explores the molecular mechanisms driving skin development and their role in skin diseases, emphasizing how disruptions in these pathways can lead to conditions like congenital disorders and cancers, potentially guiding new targeted therapies.