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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Latanoprost can make eyelashes longer, thicker, and darker.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Different types of stem cells and their environments are key to skin repair and maintenance.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.

Ruby laser pulses best destroy hair follicles during the growth phase and effectiveness varies with laser intensity; melanin is key for targeting, and timing treatments can improve results.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Skin fat helps with body temperature control and has other active roles in health.