This review discusses how herbal therapies may help manage alopecia and improve quality of life, noting their potential benefits like lower cost and fewer side effects, but emphasizes that more clinical studies are needed for validation.
83 citations
,
January 2015 in “World Journal of Stem Cells” This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.
89 citations
,
November 2014 in “International Journal of Nanomedicine” This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.
23 citations
,
June 2017 in “Drug Design Development and Therapy” This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.
6 citations
,
December 2015 in “International journal of nanomedicine” This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.
10 citations
,
April 2016 in “Research and reports in transdermal drug delivery” This review discusses the potential of follicular drug delivery systems to target the pilosebaceous unit and reports no new research findings.
130 citations
,
August 2020 in “Drug Design Development and Therapy” This review discusses various nanoparticles used to enhance skin permeation and target delivery to skin organelles, but reports no new experimental results.
28 citations
,
September 2019 in “International Journal of Nanomedicine” This study found that minoxidil nanoparticles increased drug delivery to hair follicles and improved hair growth more effectively in mice than conventional minoxidil formulations.
28 citations
,
February 2016 in “International Journal of Nanomedicine” This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.
24 citations
,
July 2018 in “Drug Design Development and Therapy” This study found that nano-transferosomal gel formulations of finasteride improved its delivery across skin layers, potentially reducing major side effects associated with oral administration for treating male pattern baldness.
13 citations
,
February 2019 in “Journal of Microencapsulation” This study focused on designing a niosome formulation that encapsulates pumpkin seed oil for topical use, achieving high entrapment efficiency and stability over three months.
1 citations
,
April 2020 in “Clinical, Cosmetic and Investigational Dermatology” In this study, topical acyclovir significantly delayed hair growth initiation and completion in mice and reduced hair follicle size, suggesting potential inhibitory effects on hair growth.
21 citations
,
July 2017 in “Journal of Cosmetic and Laser Therapy” This review discusses the research and development of vesicular carriers to enhance the delivery and effectiveness of active ingredients in cosmetic products, reporting no new clinical results.
16 citations
,
August 2014 in “International Journal of Women's Health” The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
130 citations
,
January 2017 in “International journal of nanomedicine” This study found that Na CMC hydrogel loaded with PEG-coated silver nanoparticles demonstrated superior antibacterial and wound-healing efficacy compared to commercial silver sulfadiazine cream in a wound-healing model.
39 citations
,
September 2016 in “Expert Opinion on Drug Delivery” This review explores how colloidal drug delivery systems can enhance the stability, absorption, and bioavailability of phytochemicals, potentially rediscovering ancient compounds' therapeutic benefits and overcoming limitations like poor solubility and bioavailability.
28 citations
,
March 2014 in “International Journal of Nanomedicine” This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.
24 citations
,
June 2018 in “Expert Review of Pharmacoeconomics & Outcomes Research” This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.
24 citations
,
May 2013 in “Drug Design Development and Therapy” This pilot study found that a multimodal minoxidil microemulsion with diclofenac and tea tree oil was more effective and safer than minoxidil alone for treating androgenic alopecia over 32 weeks.
23 citations
,
March 2019 in “Journal of Essential Oil Research” This study found a strong correlation between antioxidant activity and phenolic content in rosemary, influenced by bioclimatic and seasonal factors in different stages of Tunisia.
20 citations
,
August 2019 in “Expert Opinion on Drug Safety” This review examines the cognitive effects of medications for lower urinary tract symptoms and indicates that muscarinic antagonists, particularly oral oxybutynin, pose the highest risk for cognitive impairment.
20 citations
,
October 2018 in “Physics and chemistry of liquids” This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.
18 citations
,
October 2017 in “Drug Design Development and Therapy” The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.
17 citations
,
October 2016 in “Artificial Cells Nanomedicine and Biotechnology” This study found that arginine-loaded lipidic nanoparticles improved hair follicle growth in male hamsters more effectively than an aqueous arginine solution.
15 citations
,
May 2017 in “Journal of Dermatological Treatment” In this study, patients with alopecia areata experienced significant hair regrowth using topical latanoprost, minoxidil, or betamethasone valerate, with the addition of latanoprost enhancing the effectiveness of betamethasone valerate, showcasing these treatments as safe and effective options.
14 citations
,
June 2021 in “Expert Opinion on Therapeutic Patents” This review discusses various Wnt pathway modulators developed between 2014 and 2020, highlighting their potential as treatments for diseases like cancer and osteoarthritis, but reports no new clinical results.
10 citations
,
May 2021 in “Expert Opinion on Drug Delivery” This study found that CoQ10 formulated in transethosomes showed improved penetration and a better clinical response in treating androgenic alopecia compared to CoQ10 solution.
9 citations
,
March 2016 in “Natural Product Research” This study found that baicalin promotes human microvascular endothelial cell proliferation, while visnadin and minoxidil enhance tubulogenesis, with hesperidin uniquely increasing VEGFR-2 phosphorylation compared to other compounds tested.
8 citations
,
January 2018 in “PubMed” The study reported that reducing finasteride particle size significantly improved its cellular permeation through prostate epithelial cells, though it had a lesser impact on systemic pharmacokinetics and tissue distribution in rats.