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The lowest effective dose of Botox for detrusor sphincter dyssynergia is between 75-100 units.

The FDA warned about safety issues with remdesivir and tofacitinib, finasteride is linked to suicidality, potent topical corticosteroids increase osteoporosis risk, henna can cause hemolysis in G6PD deficiency, chemotherapeutic agents can cause adverse reactions, drug interactions are common in cancer patients, ketamine can reduce at-risk drinking, high dose of anticholinergics increases dementia risk in Parkinson's patients, and prenatal exposure to second-generation antipsychotics increases pregnancy complications.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

JAK inhibitors for alopecia areata are linked to minor side effects like headache and acne, but not to an increased risk of serious adverse events.

The healthcare for transgender veterans could be better with a more unified team approach.

SCDSFs from zebrafish embryos are beneficial for treating cancer, regenerating tissues, and improving conditions like psoriasis and alopecia.

Androgenetic alopecia is influenced by various factors and can be treated with medications, procedures, and non-drug methods.

Nitroglycerin ointment is now used to treat several skin conditions with fewer side effects.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

New drugs and combination therapies are improving treatment for lower urinary tract symptoms.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

Testosterone is crucial for development, growth, and various body functions in mammals.