79 citations
,
January 1975 in “Food and Cosmetics Toxicology” In this study, oxidation hair dye formulations tested on mice showed no evidence of causing systemic toxicity or cancer over an 18-month period.
70 citations
,
November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
56 citations
,
November 1958 in “The Journal of Cell Biology” This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.
44 citations
,
July 2020 in “Stem Cell Research & Therapy” This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.
38 citations
,
November 2018 in “Scientific Reports” This study suggests that chicken and alligator scales evolved independently through convergent evolution rather than sharing a common origin with avian feathers.
31 citations
,
August 2000 in “Journal of Investigative Dermatology” This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.
27 citations
,
July 2001 in “Journal of Pharmaceutical and Biomedical Analysis” Finasteride remains stable for two years with proper storage.
27 citations
,
November 2000 in “Journal of Veterinary Medicine Series B” This study found that experimentally induced iodine deficiency in growing male lambs led to hypothyroidism, resulting in stunted growth, reduced wool production, and disrupted sexual maturity.
21 citations
,
June 2017 in “Journal of The American Academy of Dermatology” This study reviewed existing articles to assess the efficacy of topical diphenylcyclopropenone immunotherapy for alopecia areata, but it did not report new clinical results.
18 citations
,
April 2021 in “PLOS ONE” This systematic review found that most level I/II clinical studies on platelet-rich plasma therapy have focused on musculoskeletal injuries, but inconsistent reporting of PRP composition complicates comparisons across medical specialties.
18 citations
,
April 2001 in “Bioorganic & Medicinal Chemistry Letters” This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.
17 citations
,
April 2021 in “Clinical Phytoscience” This review discusses the ethnobotanical uses and phytochemistry of Plumbago zeylanica L., highlighting its potential pharmacological benefits for conditions such as diabetes and cardiovascular disorders, but reports no new experimental findings.
15 citations
,
January 2014 in “Medicinal chemistry” This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.
13 citations
,
September 1976 in “Archives of Environmental Health An International Journal” In this study, Bushman women in various life stages had higher levels of iron and zinc in their hair compared to Bantu and American mothers, with iron deficiency anemia being rare among them.
12 citations
,
October 2014 in “Journal of Applied Animal Research” This study found that skin thickness in Bakerwali goats increased with age, with notable histological differences in these layers across diverse regions of the body.
12 citations
,
January 1934 in “Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character” This study found that the X-ray patterns of stretched mammalian hair (β-keratin) are similar to those of natural silk (fibrion), suggesting a similar elastic mechanism involving reversible intra-molecular transformations.
11 citations
,
December 2024 in “Wound Repair and Regeneration” In this study, researchers created the WRAHPS Guidelines to standardize the reporting of preclinical wound healing studies, aiming to improve transparency, enable comparative analysis, and support the development of human clinical trials for wound healing disorders.
11 citations
,
August 2023 in “Regenerative Therapy” This study proposes a reporting guideline, CLINIC - STRA-SVF, to standardize and improve the design and reporting of clinical studies involving SVF, highlighting its safety and effectiveness despite the low level of current evidence.
11 citations
,
January 2017 in “Evidence-based Complementary and Alternative Medicine” This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).
11 citations
,
November 1991 in “Journal of Neuropathology & Experimental Neurology” This study found that brindled mottled mice, a model of Kinky hair syndrome, exhibited abnormal development of catecholamine neurons, with increased TH-immunoreactive neurons and altered neurochemical profiles compared to controls.
10 citations
,
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” This article reviews recent hair restoration techniques evaluated in case studies at WHS/ISHRS workshops but reports no new clinical results, highlighting the need for further research with larger study groups.
8 citations
,
April 2020 in “Journal of Ethnopharmacology” This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.
8 citations
,
October 2013 in “Chemistry Central Journal” This study found that microbial transformation of dihydrotestosterone with two types of fungi produced eight metabolites, among which metabolites 5–7 were significant inhibitors of butyrylcholinesterase, suggesting potential in Alzheimer's disease management.
7 citations
,
April 2021 in “Journal of advanced pharmaceutical technology & research” This study reported that compound 16 (olean-12-en-3beta-ol, cinnamate) from Merremia peltata showed potential as an androgen receptor antagonist, suggesting it may benefit alopecia treatment based on molecular docking and ADME-Tox predictions.
6 citations
,
August 2014 in “Spectroscopy Letters” This study reported that the calculated and experimental electronic and vibrational properties of minoxidil were in good agreement, providing detailed insights into its molecular structure and thermal behaviors.
6 citations
,
January 2011 in “Springer eBooks” Nutrition is important for skin health, and changing diet can help prevent and treat skin diseases.
6 citations
,
January 2005 This study found that sodium selenite toxicity in cow calves significantly affects clinical and hematological parameters, with differing symptoms observed between subacute and chronic exposure.
6 citations
,
May 1987 in “Acta dermato-venereologica” In this study, analysis of hair root status showed similar abnormalities in both primary and secondary syphilis patients, though it remains unclear if these are specific to syphilis.
5 citations
,
January 2020 in “Skin Research and Technology” This study reported that combined oral finasteride and topical 5% minoxidil treatment in men with male-pattern hair loss improved hair growth by initiating anagen in pre-existing but deficient follicles, yet the growth rates remained unchanged and did not normalize hair productivity.
5 citations
,
January 2000 in “Inhalation Toxicology” This study found that exposure to aqueous dispersion resin in aerosol form increased lung weights and caused histopathological changes in animals at higher concentrations, with a no-observable-effect level at 30 mg/m³.