Long-Term Toxicity Studies on Oxidation Hair Dyes

January 1975 in “ Food and Cosmetics Toxicology ”

C.M. Burnett, Ben Marr Lanman, Robert P. Giovacchini, George N. Wolcott, Robert A. Scala, M.L. Keplinger

oxidation hair dyes p-phenylenediamine 2,4-toluenediamine malignant hepatomas

TLDR The hair dye formulations tested did not cause long-term toxicity or cancer in mice.

Three oxidation hair dye formulations, containing chemical intermediates such as p-phenylenediamine and 2,4-toluenediamine, were tested on 100 mice for 18 months to assess long-term toxicity and carcinogenicity. Despite previous findings that 2,4-toluenediamine could cause malignant hepatomas in rats, this study found no evidence of systemic toxicity or carcinogenicity from the hair dye formulations.

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