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Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Teak leaf extract contains compounds that could help treat hair loss.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Hair loss in men is common, treatable, but not curable.

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Reliable method detects finasteride in human plasma at low doses.

New treatments for male hypogonadism are effective and should be personalized.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Post-finasteride syndrome's existence is uncertain; more research needed.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

Teak is a durable, termite-resistant wood with medicinal benefits.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.