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    Did you mean Nonsteroidal Inhibitors?
    Glossary Nonsteroidal Inhibitors

    compounds that block biological processes without using steroids

    Nonsteroidal inhibitors are compounds that block specific biological processes without using steroid structures. In the context of hair and alopecia, these inhibitors can target enzymes or pathways involved in hair loss, such as 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), a hormone linked to hair thinning and loss.

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    1. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 25 citations
    2. A new label-free screen for steroid 5α-reductase inhibitors using LC-MS Steroids · 2016 · 15 citations
    3. Search for New antineoplastic agents based on structural modifications of steroidal 5α-reductase, 17β-hydroxysteroid dehydrogenase, and 17α-hydroxylase/17,20-lyase inhibitors Russian Journal of Oncology · 2025
    4. Design, synthesis and structure-activity relationships studies on steroidal aromatase and 5α-reductase inhibitors as anti-tumors Estudo Geral (Universidade de Coimbra) · 2013
    5. Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2003 · 37 citations
    6. Steroid inhibitors of androgen-potentiated actions on skin 1983 · 4 citations
    7. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    8. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    9. 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1 Bioorganic & medicinal chemistry letters · 2007 · 13 citations
    10. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
    11. Steroid 5&#945;-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003 · 42 citations
    12. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    13. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    14. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    15. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 2005 · 44 citations
    16. Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase Helvetica Chimica Acta · 1995 · 8 citations
    17. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    18. 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives International Journal of Biological Macromolecules · 2011 · 26 citations
    19. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    20. N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Bioorganic & Medicinal Chemistry Letters · 2004 · 17 citations
    21. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 1 citations
    22. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis Hormone Molecular Biology and Clinical Investigation · 2014 · 15 citations
    23. Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2017 · 13 citations
    24. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    25. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    26. Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment 2015 · 4 citations
    27. The Mechanisms of Anabolic Steroids, Selective Androgen Receptor Modulators and Myostatin Inhibitors 대한스포츠의학회지 · 2022 · 2 citations
    28. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    29. Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite Therapeutic Drug Monitoring · 2007 · 39 citations
    30. A Review on Steroidal 5&#945;-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2011 · 17 citations