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The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Dutasteride may protect the brain in early Parkinson's disease.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

Men with liver cancer have higher levels of a specific testosterone byproduct in their liver and blood, despite overall lower male hormone levels.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

A new compound effectively inhibits human 5α-reductase 1.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Mycophenolate mofetil helped reduce steroid use in treating a dog's autoimmune skin disease.

A boy with a rare skin condition and kidney disease improved with cyclosporine after steroids failed, suggesting a new treatment approach.