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Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Finasteride doesn't affect erections much, but may decrease libido in men.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Dutasteride is more efficient than finasteride, but individual results vary.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

New compounds may help treat prostate cancer by reducing cell growth.