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30 / 1000+ results![Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2](/images/research/0edfee8f-15dc-47db-9731-98db20bbf42a/small/12033.jpg)
research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2
Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.
![LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.](/images/research/68a7e7ae-c0f6-44ff-9c45-522709cd10e9/small/21099.jpg)
research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
![Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors](/images/research/f98c5862-b8ba-42a9-8db7-094c861f3c1e/small/13422.jpg)
research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
![Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur](/images/research/1866b9e2-78d7-4574-af22-f5e00a0c7245/small/31700.jpg)
research Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur
The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.
research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data
Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.
![Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men.](/images/research/5dffb625-25e7-43e8-9210-946b3a34df2a/small/2067.jpg)
research Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men.
Finasteride doesn't affect erections much, but may decrease libido in men.
![The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases](/images/research/43f845a1-e361-471f-b8b3-1564c4a4abfe/small/14689.jpg)
research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
![Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors](/images/research/bbcb8aad-ede5-4f7d-a11c-428136f4745a/small/17940.jpg)
research Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors
Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
![Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism](/images/research/20f9c984-a193-4adc-b3cb-9811a6ade073/small/31784.jpg)
research Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
![Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells](/images/research/cfa3b4ff-0d44-44ac-aed1-689172d42771/small/14133.jpg)
research Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells
Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.
![5α-Reduced glucocorticoids: a story of natural selection](/images/research/399ca7ee-d7f0-422d-a36b-6b1e0b85f4f4/small/26132.jpg)
research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
![5α-Reductases In Human Physiology: an Unfolding Story](/images/research/6a65600c-6416-41eb-9e39-2cc026dfc669/small/14635.jpg)
research 5α-Reductases In Human Physiology: an Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
![5α-Reductases in Human Physiology: An Unfolding Story](/images/research/746bae71-c929-4ff5-a2d7-142ec295d02c/small/14697.jpg)
research 5α-Reductases in Human Physiology: An Unfolding Story
Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
![Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.](/images/research/0cbb0e81-3fd6-46bb-b245-a382219c25c4/small/1982.jpg)
research Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.
Four-amino acid part makes enzyme sensitive to finasteride.
![Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride](/images/research/fa3cdf0c-c7b7-4025-9d4e-121a4258f109/small/4968.jpg)
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
![Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study](/images/research/2dd222fc-c03e-49fe-839a-267537509c3b/small/31829.jpg)
research Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study
Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.
![Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase](/images/research/66e4646f-8129-40fe-84f0-f0d93a41b309/small/21103.jpg)
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.
research Estrogen and androgen signaling in the pathogenesis of BPH
Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
![Skin steroidogenesis in health and disease](/images/research/38c91137-04e7-4c70-8ca1-baac66c18b75/small/14111.jpg)
research Skin steroidogenesis in health and disease
The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
![Selective non-steroidal inhibitors of 5α-reductase type 1](/images/research/a5e4b579-dcaf-44af-ac22-a1392f115f7b/small/28705.jpg)
research Selective non-steroidal inhibitors of 5α-reductase type 1
Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
![Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders](/images/research/0ac502d1-33ba-4a20-bd13-a6b5c37069b5/small/26242.jpg)
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
![Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates](/images/research/c1133907-1cfc-45ac-977d-db8aa89d2d70/small/12113.jpg)
research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates
Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
![5-Alpha reductase deficiency](/images/research/170ee7d3-4c59-4976-ae3e-f58031d6a5ea/small/14401.jpg)
research 5-Alpha reductase deficiency
5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.
![Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review](/images/research/68d4e74a-4b26-4fff-a65d-cac0576324ec/small/14498.jpg)
research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review
5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
![Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase](/images/research/5cea0dec-640c-403b-b8ad-66fc23c654fa/small/15507.jpg)
research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase
LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.
![Structure of human type II 5 alpha-reductase gene.](/images/research/fbfe5710-175b-46df-a180-ed83888622dc/small/21117.jpg)
research Structure of human type II 5 alpha-reductase gene.
The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.
![Structure of human type II 5 alpha-reductase gene](/images/research/201f02ee-9a9a-4148-a23f-8c881cf1b950/small/21118.jpg)
research Structure of human type II 5 alpha-reductase gene
The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.
![Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens](/images/research/eef64229-a318-4401-9078-f2eacee058ec/small/21068.jpg)
research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
![Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase](/images/research/f6a78f52-c8c4-43a6-bf54-5f4b30058b44/small/28685.jpg)
research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase
Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.