Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this comprehensive review, researchers examine the p63 gene's crucial role in skin development and pathology, highlighting its regulation of cell processes and its potential therapeutic implications for disorders like ectodermal dysplasia.

This review synthesizes current knowledge on hair follicle biology in androgenetic alopecia and explores potential regenerative therapies, but it reports no new clinical results.

This narrative review explores molecular signaling pathways and their impact on hair follicle microenvironments in androgenetic alopecia, alongside potential treatments like stromal vascular fraction therapies and exosome-based strategies.

This review integrates current understanding of hair follicle biology and signaling pathways into a comprehensive framework for androgenetic alopecia, but presents no new empirical findings.

This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.

This review identified emerging therapies for androgenetic alopecia, such as low-dose oral minoxidil and stem cell-based treatments, which show promise for improved hair loss management but require standardized protocols and large-scale trials for further validation.

In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.

This study suggests that macrophages play a more substantial role in the pathogenesis of Lichen planopilaris compared to Frontal fibrosing alopecia, as indicated by increased CD68+ cells in Lichen planopilaris.

This review discusses the causes, diagnosis, and treatment of pediatric alopecia, emphasizing early diagnosis and considering holistic approaches, but reports no new clinical results.

In this review, researchers critically examine contemporary treatments for androgenetic alopecia, emphasizing advanced drug delivery systems, regenerative medicine, and emerging molecular targets, while identifying significant gaps that hinder translating these innovations into clinical practice.

This review examines how regenerative therapies targeting shared biological pathways can promote healing in musculoskeletal disorders and hair follicle dysfunction, highlighting modalities like platelet-rich plasma and laser therapy while addressing challenges in standardization and measurement.

Prostaglandin helps regenerate hair follicles after radiation damage.

This research discusses the shift in cosmetic dermatology towards integrating regenerative medicine, AI, and personalized care, highlighting their potential to improve aesthetic outcomes and skin function while considering ethical and regulatory challenges.

This study developed immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) as a consistent source of therapeutic secretome, reporting their superior immunomodulatory and regenerative performance, potentially advancing cell-free therapies for inflammation and tissue repair.

This review highlights the potential of plant-derived bioactive compounds as an alternative to current hair loss treatments by detailing the mechanisms and clinical evidence of eighteen traditional medicinal plants, and discusses future trends like nanotechnology and stem cell therapy in managing alopecia.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

This review discusses the potential of mesenchymal stem cell therapies for treating various skin diseases, including vitiligo, alopecia, and epidermolysis bullosa, but reports no new results.

This review explores the role of nanotechnology in wound healing, highlighting its potential through antimicrobial properties, selective inflammatory action, angiogenesis promotion, and its use in drug and gene delivery.

This study suggests that age-related regenerative decline in hair follicles may be due to an imbalance of signals affecting stem cell activation, with follistatin potentially promoting renewal.

In this study, researchers observed that patients with androgenetic alopecia show differences in scalp microbial communities compared to the general population, including an increase in Cutibacterium acnes, particularly in males, which may interact with lipid and immune pathways to contribute to hair follicle miniaturization.

This study found that the X-linked gene UTX is crucial for regulating skin differentiation and inflammation in females by affecting retinoic acid signaling, also highlighting potential links to sex disparities in skin diseases.

This study found that small extracellular vesicles derived from human adipose tissue could promote soft tissue regeneration and increase M2 macrophage polarization, suggesting a promising cell-free approach to tissue repair.

This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.

This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.

In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.

This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.

This study found that intra-follicular Wnt signaling and dermal BMP signaling oscillate differently during hair cycling in mice, affecting hair wave propagation and phases of hair growth.

This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.

This review discusses the use of stem cells and stem cell-derived products in burn wound healing, highlighting various stem cell sources, associated signaling pathways, and delivery methods, but reports no new clinical results.

In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.