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GlossarySignal Transducer and Activator of Transcription 5 (STAT5)

protein that transmits signals to influence gene expression

Signal Transducer and Activator of Transcription 5 (STAT5) is a protein that plays a crucial role in transmitting signals from the cell surface to the nucleus, where it can influence gene expression. It is particularly important in processes like cell growth, differentiation, and immune function. In the context of hair biology, STAT5 can be involved in the regulation of hair follicle development and cycling.

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Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

815 citations, April 2010 in “The Journal of Clinical Endocrinology & Metabolism”

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations, November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research COVID-19 and Endocrine and Metabolic Diseases: An Updated Statement from the European Society of Endocrinology

68 citations, May 2021 in “Endocrine”

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations, October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations, April 2016 in “Journal of Investigative Dermatology”

STAT5 activation is crucial for starting the hair growth phase.

research State-Dependent Signaling by Cav1.2 Regulates Hair Follicle Stem Cell Function

27 citations, June 2013 in “Genes & development”

Ca_v1.2 affects hair growth and could be a target for hair loss treatments.

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

research 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

26 citations, October 2016 in “Biomolecules & Therapeutics”

3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.

research Status of Sex Reassignment Surgery for Gender Identity Disorder in Japan

19 citations, February 2012 in “International Journal of Urology”

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations, January 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

research Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

13 citations, October 2017 in “Bioscience, Biotechnology, and Biochemistry”

Centella asiatica extract may help promote hair growth by blocking a specific cell signaling pathway.

research Status of Medical Treatment for Androgenetic Alopecia

13 citations, October 1993 in “International Journal of Dermatology”

Minoxidil effectively promotes hair regrowth in younger patients with small balding areas.

research Ovary And Uterus Related Adverse Events Associated With Statin Use: An Analysis Of The FDA Adverse Event Reporting System

11 citations, July 2020 in “Scientific Reports”

Statins may be linked to reproductive organ conditions, and their risks should be monitored.

research Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration

11 citations, November 2015 in “Experimental Dermatology”

The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.

research Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

6 citations, November 2021 in “Frontiers in immunology”

STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

research Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis Through STAT3 Signal Pathway in Glioma Cells

6 citations, January 2015 in “Evidence-based Complementary and Alternative Medicine”

Saw palmetto extract may help treat brain tumors by blocking a specific growth signal and blood vessel formation.

research Evaluating Statistics in Clinical Trials: Making the Unintelligible Intelligible

5 citations, October 2008 in “Australasian Journal of Dermatology”

Doctors need to understand statistics to properly evaluate clinical trials for patient care.

research Broussonetia Papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

4 citations, June 2020 in “Cosmetics”

Broussonetia papyrifera extract helps hair growth by regulating specific proteins.

research Stat3 Partly Inhibits Cell Proliferation Via Direct Negative Regulation of FST Gene Expression

3 citations, June 2021 in “Frontiers in genetics”

The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations, April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Status of Scalp Hair and Therapy of Alopecia in Men in Switzerland

2 citations, February 2001 in “PubMed”

In Switzerland, 43% of men experience hair loss, and many switch to Propecia for treatment.

research Impairment of Hair-Inducing Capacity of Three-Dimensionally Cultured Human Dermal Papilla Cells by the Ablation of STAT5

1 citations, January 2019 in “Annals of dermatology/Annals of Dermatology”

STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.

STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

1 citations, August 2016 in “Journal of Investigative Dermatology”

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells

April 2018 in “Journal of Investigative Dermatology”

Blocking a specific immune cell signal can trigger hair growth.