October 2023 in “Paediatrics & child health” This document serves as a resource for pediatricians and primary care providers to guide gender-affirming health care for transgender and gender-diverse youth, including potential medical transition options.
This chapter reviews the prevalence, pathogenesis, and management of hair and scalp disorders but reports no new clinical findings.
36 citations
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June 2017 in “Journal of Cutaneous Medicine and Surgery” This review develops expert-guided recommendations for hidradenitis suppurativa management, highlighting evidence for the effectiveness of antibacterial and anti-tumor necrosis factor therapies, but reports no new clinical trial results.
31 citations
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March 2017 in “Journal of The American Academy of Dermatology” This study observed various patterns of permanent alopecia in breast cancer patients treated with taxanes and adjuvant hormonal chemotherapy, hypothesizing disruptions in hair follicle cycles due to chemoinflammatory and hormonal factors.
4 citations
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June 2002 in “Clinical and experimental dermatology” This review discusses current treatments and management strategies for hidradenitis suppurativa, noting the mixed effectiveness of various therapies, including surgery, antibiotics, and hormonal treatments, but reports no new clinical findings.
June 2008 in “British Journal of Dermatology” Herpes gestationis is linked to certain antigens, atopic eczema affects T cell populations and may be eased by breastfeeding, higher doses of anti-androgen treatment can improve androgenic alopecia, topical minoxidil increases hair thickness, long-term methotrexate therapy can cause liver fibrosis in psoriasis patients, and Lichen Sclerosus et Atrophicus patients aren't at higher risk for autoimmune disorders.
128 citations
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September 2013 in “Journal of Clinical Epidemiology” This study developed a framework to handle missing participant data in systematic reviews for continuous outcomes, finding varied impacts on confidence in effect estimates across reviewed cases.
119 citations
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July 2016 in “Annals of the New York Academy of Sciences” This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
115 citations
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October 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, researchers identified novel LMNA mutations in patients with atypical progeroid syndrome, revealing clinical features distinct from other similar disorders, but unrelated to mutant prelamin A accumulation.
61 citations
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March 2009 in “The Journal of the American Board of Family Medicine” This article reviews current diagnostic and treatment approaches for discoid lupus erythematosus, emphasizing the importance of early treatment and photoprotection, but reports no new clinical findings.
60 citations
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March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that RANK-RANKL signaling regulates hair renewal and epidermal homeostasis in mice, revealing its role in initiating hair growth cycles and maintaining skin cell activity.
59 citations
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April 2016 in “Breast Cancer Research and Treatment” This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.
59 citations
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September 2008 in “Journal of Burn Care & Research” This study found that a new topical nitric oxide gel significantly accelerated burn wound healing in mice by enhancing re-epithelialization, hair follicle regeneration, collagen deposition, and angiogenesis compared to controls.
54 citations
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October 2019 in “Cochrane library” This study found low- to very low-quality evidence suggesting that several pharmacological treatments, including alpha blockers and antibiotics, may reduce prostatitis symptoms without significantly increasing adverse events in the short term, although more rigorous trials are needed.
49 citations
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April 2016 in “International journal of molecular sciences” This study found that shift nurses exhibited lower circadian variations compared to daytime nurses, indicating an adjustment of their biological clocks to continuous shift schedules.
43 citations
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January 1977 in “Toxicology and Applied Pharmacology” In this study, minoxidil was found to have low toxicity in various animals, with specific heart lesions observed only in dogs at certain doses.
41 citations
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November 2013 in “Experimental Dermatology” This study found that leptin acts as an inducer of the anagen phase in hair follicles, suggesting its role as a potential player in hair biology.
27 citations
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August 2015 in “Experimental Dermatology” In this study, electrical stimuli at low voltage and frequency settings promoted hair growth in vitro and in rabbit models, possibly by activating pathways like Wnt/β-catenin.
19 citations
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September 2020 in “Pharmaceutics” This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
15 citations
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September 2018 in “Dermatologic therapy” In this study, the use of two emollients significantly reduced itching severity in individuals with xerotic eczema, starting 30 minutes post-application, and improved skin moisture and lipid content over 14 days, while demonstrating good tolerance with few adverse events.
6 citations
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December 2020 in “Dermatological reviews” This review discusses the potential link between androgenic alopecia, androgens, and the severity of COVID-19, highlighting possible therapeutic targets but reports no new clinical results.
4 citations
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June 2025 in “Cochrane Database of Systematic Reviews” This Cochrane review found no clear superiority among treatments for central serous chorioretinopathy, with low-dose photodynamic therapy, supplements, and eplerenone showing slightly higher probabilities of improving visual acuity, but evidence remains uncertain due to biases and small study sizes.
2 citations
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October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
1 citations
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December 2017 in “Research for Rural Development/Research for Rural Development (Online)” This study found no correlation between clinical signs and sex steroid levels in ferrets with hyperadrenocorticism and noted that androstenedione was elevated in many cases.
April 2025 in “Journal of the Association for Research in Otolaryngology” In this study, researchers observed that inhibiting myosin light chain kinase in hair cells reduced stiffness and oscillation in bullfrog hair bundles and increased hearing thresholds in mice.
September 2023 in “Dermatology and therapy” In this phase 2b/3 trial, ritlecitinib showed effectiveness in treating alopecia areata patients with varying hair loss profiles, significantly improving patient-reported outcomes for hair regrowth and satisfaction compared to placebo, regardless of the hair loss type and extent at baseline.
44 citations
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April 2017 in “Genes & development” This study identified hair shaft progenitors in the matrix that regulate hair growth and pigmentation by creating a niche dependent on stem cell factor, implicating KROX20+ cells in these processes.
10 citations
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July 2021 in “International Journal of Rheumatic Diseases” This review summarizes evidence indicating that body image issues in patients with systemic lupus erythematosus should be addressed with the same importance as physical symptoms like pain and disability.
4 citations
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May 2019 in “Skin Research and Technology” This study found that male pattern hair loss worsened significantly after stopping finasteride, revealing a "rebound effect" where terminal hair transformed into miniaturized hair over 30 months off the drug.
2 citations
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June 2020 in “Skin Research and Technology” This study found that scalp thickness and hair follicle depth were reduced in individuals with androgenetic alopecia, and MRI signal intensity was higher compared to those without the condition.