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Advanced human skin models improve drug development and could replace animal testing.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

Effective management of children's hair loss involves accurate diagnosis, various treatments, and supportive care.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

Loose anagen hair syndrome, often affecting young girls, can be diagnosed with a hair-pull test and usually gets better on its own, but severe cases may need treatment.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.