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      Retinoids in Scarless Skin Regeneration: From Molecular Mechanisms to Therapeutic Strategies

      research Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies

      September 2025 in “Frontiers in Cell and Developmental Biology”
      In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.
      Traditional Uses, Phytochemistry, Pharmacology, Toxicity and Clinical Application of Traditional Chinese Medicine Cynoglossum Amabile: A Review

      research Traditional uses, phytochemistry, pharmacology, toxicity and clinical application of traditional Chinese medicine Cynoglossum amabile: a review

      April 2024 in “Frontiers in pharmacology”
      This review of Cynoglossum amabile, a traditional Chinese and ethnomedicine, provides insights into its uses, chemical components, biological activities, and toxicity. Highlighting its market potential, the study underscores the importance of indigenous knowledge in drug development despite noted hepatotoxic risk linked to its pyrrolizidine alkaloids.
      Plant Elicitor Peptides Regulate Root Hair Development in Arabidopsis

      research Plant elicitor Peptides regulate root hair development in Arabidopsis

      February 2024 in “Frontiers in plant science”
      This study found that Plant Elicitor Peptides enhance root hair growth through a mechanism independent of their known receptors, with PROPEP2 playing a key role in this process by influencing gene expression related to root hair formation.
      Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

      research Epidermal homeostasis: a balancing act of stem cells in the skin

      1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”
      This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.
      Mechanisms Regulating Skin Immunity and Inflammation

      research Mechanisms regulating skin immunity and inflammation

      610 citations , April 2014 in “Nature Reviews Immunology”
      This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.
      Modulating the Stem Cell Niche for Tissue Regeneration

      research Modulating the stem cell niche for tissue regeneration

      480 citations , August 2014 in “Nature Biotechnology”
      This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
      Alginate and Its Application to Tissue Engineering

      research Alginate and its application to tissue engineering

      425 citations , January 2021 in “SN Applied Sciences”
      This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
      The Neurobiology of Sexual Function

      research The Neurobiology of Sexual Function

      393 citations , November 2000 in “Archives of General Psychiatry”
      This review discusses the neurobiology of sexual function and reports no new results; the authors cover multiple endocrine and neurotransmitter influences on sexual desire, arousal, and orgasm stages.
      The Hair Cycle

      research The hair cycle

      375 citations , February 2006 in “Journal of Cell Science”
      This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.
      Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

      research Long-term renewal of hair follicles from clonogenic multipotent stem cells

      291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”
      This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
      Hoxc13 Mutant Mice Lack External Hair

      research Hoxc13 mutant mice lack external hair

      245 citations , January 1998 in “Genes & Development”
      This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.
      Telogen Effluvium: A Comprehensive Review

      research Telogen Effluvium

      214 citations , March 1993 in “Archives of Dermatology”
      This article proposes five different mechanisms for telogen effluvium, supported by clinical findings, based on changes in different phases of the hair cycle.
      Hair Cosmetics: An Overview

      research Hair cosmetics: An overview

      193 citations , January 2015 in “International journal of trichology”
      This review examines hair cosmetics, including shampoos and conditioners, for their formulations and effects, but reports no new clinical findings; it emphasizes the importance of dermatologist knowledge in treating diverse hair conditions.
      The Human Tri-Peptide GHK and Tissue Remodeling

      research The human tri-peptide GHK and tissue remodeling

      165 citations , January 2008 in “Journal of biomaterials science. Polymer ed.”
      This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
      Hair Follicle Stem Cells: Walking the Maze

      research Hair follicle stem cells: Walking the maze

      165 citations , June 2007 in “European Journal of Cell Biology”
      This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
      Transplantation Immunology: Solid Organ and Bone Marrow

      research Transplantation immunology: Solid organ and bone marrow

      139 citations , February 2010 in “ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology”
      This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
      Hair Anatomy for the Clinician

      research Hair anatomy for the clinician

      139 citations , July 1991 in “Journal of The American Academy of Dermatology”
      This article discusses the structure of hair follicles and their significance in evaluating hair disorders, but it does not report any new research findings.
      Morpho-Regulation of Ectodermal Organs

      research Morpho-Regulation of Ectodermal Organs

      131 citations , March 2004 in “˜The œAmerican journal of pathology”
      This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.
      Keratin Disorders: From Gene to Therapy

      research Keratin disorders: from gene to therapy

      109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”
      This review discusses keratin disorders and potential RNA interference therapeutics, reporting no new clinical findings but highlighting the promise of siRNA for future treatments.